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Nat Rev Dis PrimersBiliary atresia (BA) is a progressive inflammatory fibrosclerosing disease of the biliary system and a major cause of neonatal cholestasis. It affects 1:5,000-20,000 live births, with the highest incidence in Asia. The pathogenesis is still unknown, but emerging research suggests a role for ciliary dysfunction, redox stress and hypoxia.
Tam PKH +9 more
europepmc +4 more sources
Genetic Factors and Their Role in the Pathogenesis of Biliary Atresia
Frontiers in Pediatrics, 2022 Biliary Atresia, a common basis for neonatal cholestasis and primary indication for Liver Transplantation, accounts for 60% of pediatric Liver Transplantations.
Li-Na Wu +7 more
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Current and emerging adjuvant therapies in biliary atresia
Frontiers in Pediatrics, 2022 Following Kasai hepatic portoenterostomy (HPE), most patients with biliary atresia will eventually require liver transplantation due to progressive cirrhosis and liver failure.
Scott C. Fligor +4 more
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Diagnostics, 2021 Biliary atresia is an aggressive liver disease of infancy and can cause death without timely surgical intervention. Early diagnosis of biliary atresia is critical to the recovery of bile drainage and long-term transplant-free survival.
Wenying Zhou, Luyao Zhou
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Impacts of Early Kasai Portoenterostomy on Short‐Term and Long‐Term Outcomes of Biliary Atresia
Hepatology Communications, 2021 There are discrepancies regarding the clinical impact of age at Kasai portoenterostomy (KP) on surgical outcomes. Hence, we re‐assessed the clinical significance of age at KP.
Ryuji Okubo +3 more
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Prognosis of Biliary Atresia Associated With Cytomegalovirus: A Meta-Analysis
Frontiers in Pediatrics, 2021 Objective: The etiology of biliary atresia is unclear, but viral infection has been implicated. The aim of the current meta-analysis was to investigate relationships between cytomegalovirus (CMV) and the prognosis of biliary atresia.Methods: PubMed ...
Yilin Zhao +8 more
doaj +2 more sources
Biliary atresia: pathology, etiology and pathogenesis
Future Science OA, 2020 Biliary atresia is a progressive fibrosing obstructive cholangiopathy of the intrahepatic and extrahepatic biliary system, resulting in obstruction of bile flow and neonatal jaundice.
Mukul Vij, Mohamed Rela
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An Ensembled Deep Learning Model Outperforms Human Experts in Diagnosing Biliary Atresia from Sonographic Gallbladder Images [PDF]
medRxiv, 2020 It is still difficult to make accurate diagnosis of biliary atresia (BA) by sonographic gallbladder images particularly in rural area lacking relevant expertise.
Wenying Zhou +16 more
openalex +2 more sources
Annals of Hepatology, 2021 Introduction and objectives: Differentiating biliary atresia from other causes of neonatal cholestasis is challenging, particularly when cytomegalovirus (CMV) and biliary atresia occur simultaneously.
Dongying Zhao +6 more
doaj +2 more sources
The Association Between Biliary Atresia and Cytomegalovirus Infection [PDF]
, 2017 Perinatal infection of cytomegalovirus (CMV) may cause cholestasis resembling biliary atresia. CMV infection is found in patients with biliary atresia. This simultaneous occurrence of biliary atresia and CMV infection prompted
Kumaheri, M. A. (Meutia) +1 more
core +3 more sources