Results 21 to 30 of about 222,722 (307)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia

Hepatology, 2021
Biliary atresia is a severe inflammatory and fibrosing cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a prenatal onset of liver dysfunction.
S. Amarachintha, Reena Mourya, Hiroaki Ayabe, Li Yang, Zhenhua Luo, Xiaofeng Li, Unmesha Thanekar, P. Shivakumar, J. Bezerra   +8 more
semanticscholar   +1 more source

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Alagille Syndrome Mimicking Biliary Atresia in Early Infancy. [PDF]

PLoS ONE, 2015
Alagille syndrome may mimic biliary atresia in early infancy. Since mutations in JAG1 typical for Alagille syndrome type 1 have also been found in biliary atresia, we aimed to identify JAG1 mutations in newborns with proven biliary atresia (n = 72). Five
Tomáš Dědič, Milan Jirsa, Radan Keil, Michal Rygl, Jiri Šnajdauf, Radana Kotalová   +5 more
doaj   +1 more source

Ensembled deep learning model outperforms human experts in diagnosing biliary atresia from sonographic gallbladder images

Nature Communications, 2021
It is still challenging to make accurate diagnosis of biliary atresia (BA) with sonographic gallbladder images particularly in rural area without relevant expertise.
Wenying Zhou, Yang Yang, Cheng Yu, Juxian Liu, Xingxing Duan, Zongjie Weng, Dan Chen, Qianhong Liang, Qin Fang, Jiaojiao Zhou, Hao Ju, Zhenhua Luo, Weihao Guo, Xiaoyan Ma, Xiaoyan Xie, Ruixuan Wang, Lu-yao Zhou   +16 more
semanticscholar   +1 more source

Value of the International Classification of Diseases code for identifying children with biliary atresia [PDF]

Clinical and Experimental Pediatrics, 2021
Background Although identifying cases in large administrative databases may aid future research studies, previous reports demonstrated that the use of the International Classification of Diseases, Tenth Revision (ICD-10) code alone for diagnosis leads to
Pornthep Tanpowpong, Chatmanee Lertudomphonwanit, Pornpimon Phuapradit, Suporn Treepongkaruna   +3 more
doaj   +1 more source

Organoids in biliary atresia. [PDF]

World J Pediatr Surg
Organoids are three-dimensional and self-organizing cell cultures of various lineages that resemble structures and functions of an organ in many ways, and they are versatile tools in disease modeling and patho-mechanistic study of human diseases affecting their tissues of origin.
Lui VCH.
europepmc   +4 more sources

Biliary Atresia: Clinical Phenotypes and Aetiological Heterogeneity

Journal of Clinical Medicine, 2021
Biliary atresia (BA) is an obliterative condition of the biliary tract that presents with persistent jaundice and pale stools typically in the first few weeks of life. While this phenotypic signature may be broadly similar by the time of presentation, it
M. Davenport, Ancuta Muntean, N. Hadžić   +2 more
semanticscholar   +1 more source

Nilai Diagnostik Ultrasonografi Hepatobilier sebagai Prediktor Atresiabilier pada Kolestasis Bayi di RSUP Sanglah Denpasar Tahun 2017 - 2021

Jurnal Kesehatan Andalas, 2023
Hepatobiliary ultrasound is the most common initial diagnostic modality in the early detection of biliary atresia. It is not the gold standard, but the hepatobiliary ultrasound examination can be used to determine the appropriate further management ...
Kristin Agustina, Pande Putu Yuli Anandasari, Firman Parulian Sitanggang, I Wayan Gede Artawan Eka Putra, Made Widhi Asih, Putu Patriawan   +5 more
doaj   +1 more source

Diagnostic Yield of Newborn Screening for Biliary Atresia Using Direct or Conjugated Bilirubin Measurements.

Journal of the American Medical Association (JAMA), 2020
Importance Treating biliary atresia in newborns earlier can delay or prevent the need for liver transplant; however, treatment typically occurs later because biliary atresia is difficult to detect during its early stages.
S. Harpavat, J. Garcia-Prats, C. Anaya, M. Brandt, P. Lupo, M. Finegold, A. Obuobi, A. Elhennawy, W. S. Jarriel, B. Shneider   +9 more
semanticscholar   +1 more source