Results 11 to 20 of about 83,082 (294)

Establishment and characterization of an immortalized epithelial cell line from human gallbladder

Frontiers in Oncology, 2022
BackgroundAlthough a plethora of studies have employed multiple gallbladder cancer (GBC) cell lines, it is surprisingly noted that there is still lack of a normal gallbladder epithelial cell line as a normal counterpart, thus impeding substantially the ...
Ziyi Wang, Ziyi Wang, Ziyi Wang, Ziyi Wang, Shijia Wang, Shijia Wang, Shijia Wang, Shijia Wang, Ziheng Jia, Ziheng Jia, Ziheng Jia, Ziheng Jia, Yuhao Zhao, Yuhao Zhao, Yuhao Zhao, Yuhao Zhao, Mao Yang, Mao Yang, Mao Yang, Mao Yang, Weikang Yan, Weikang Yan, Weikang Yan, Weikang Yan, Tao Chen, Tao Chen, Tao Chen, Tao Chen, Dongxi Xiang, Dongxi Xiang, Dongxi Xiang, Rong Shao, Rong Shao, Rong Shao, Rong Shao, Rong Shao, Yingbin Liu, Yingbin Liu, Yingbin Liu, Yingbin Liu   +39 more
doaj   +1 more source

The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1

Journal of Translational Medicine, 2023
Background Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pathway, and its abnormality leads to
Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu, Ying Huang   +9 more
doaj   +1 more source

Development and Validation of a Prognostic Nomogram Based on the Systemic Immune-Inflammation Index for Resectable Gallbladder Cancer to Predict Survival and Chemotherapy Benefit

Frontiers in Oncology, 2021
ObjectivesTo investigate the prognostic significance of the systemic immune-inflammation index (SII) in patients after radical cholecystectomy for gallbladder cancer (GBC) using overall survival (OS) as the primary outcome measure.MethodsBased on data ...
Lin Li, Lin Li, Lin Li, Lin Li, Tai Ren, Tai Ren, Tai Ren, Ke Liu, Ke Liu, Ke Liu, Ke Liu, Mao-Lan Li, Mao-Lan Li, Mao-Lan Li, Ya-Jun Geng, Ya-Jun Geng, Ya-Jun Geng, Ya-Jun Geng, Yang Yang, Yang Yang, Yang Yang, Yang Yang, Huai-Feng Li, Huai-Feng Li, Huai-Feng Li, Xue-Chuan Li, Xue-Chuan Li, Xue-Chuan Li, Xue-Chuan Li, Run-Fa Bao, Run-Fa Bao, Run-Fa Bao, Yi-Jun Shu, Yi-Jun Shu, Yi-Jun Shu, Hao Weng, Hao Weng, Hao Weng, Wei Gong, Wei Gong, Wei Gong, Wan Yee Lau, Xiang-Song Wu, Xiang-Song Wu, Xiang-Song Wu, Ying-Bin Liu, Ying-Bin Liu, Ying-Bin Liu, Ying-Bin Liu   +48 more
doaj   +1 more source

Evaluation of a 12-mm diameter covered self-expandable end bare metal stent for malignant biliary obstruction

Endoscopy International Open, 2018
Background and study aims Biliary metallic stents are used to drain unresectable malignant distal biliary obstructions. This study aimed to evaluate the efficacy of a novel 12-mm-diameter covered, self-expandable end bare metal stent (12-mm CSEEMS).
Kazunori Nakaoka, Senju Hashimoto, Naoto Kawabe, Takuji Nakano, Toshiki Kan, Masashi Ohki, Yuka Ochi, Tomoki Takamura, Takamitsu Kurashita, Sayuri Nomura, Keishi Koyama, Aiko Fukui, Kentaro Yoshioka   +12 more
doaj   +1 more source

KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H ₂S axis and contributes to pancreatic cancer growth

Acta Biochimica et Biophysica Sinica, 2022
In pancreatic cancer, KRAS G12D can trigger pancreatic cancer initiation and development. Rapid tumor growth is often accompanied by excess intracellular reactive oxygen species (ROS) production, which is unfavorable to tumor.
Fan Kun, Zhang Shulong, Ni Xiaojian, Shen Sheng, Wang Jiwen, Sun Wentao, Suo Tao, Liu Han, Ni Xiaoling, Liu Houbao   +9 more
doaj   +1 more source

Biliary drainage in malignant biliary obstruction: an umbrella review of randomized controlled trials

Frontiers in Oncology, 2023
BackgroundThere are still many controversies about biliary drainage in MBO, and we aimed to summarize and evaluate the evidence associated with biliary drainage.MethodsWe conducted an umbrella review of SRoMAs based on RCTs. Through July 28, 2022, Embase,
Yaoqun Wang, Yaoqun Wang, Ningyuan Wen, Ningyuan Wen, Xianze Xiong, Bei Li, Bei Li, Jiong Lu, Jiong Lu   +8 more
doaj   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Organoids: The current status and biomedical applications

MedComm, 2023
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are derived from cells with stem potential and can self‐organize and differentiate into 3D cell masses, recapitulating the morphology and functions of their in vivo ...
Siqi Yang, Haijie Hu, Hengchung Kung, Ruiqi Zou, Yushi Dai, Yafei Hu, Tiantian Wang, Tianrun Lv, Jun Yu, Fuyu Li   +9 more
doaj   +1 more source

“Steinstrasse” in the Biliary Tract

The Eurasian Journal of Medicine, 2017
The presence of a stone or stones within the common bile duct (CBD) is known as choledocholithiasis. Choledocholithiasis is reported in 3%-22% of patients undergoing cholecystectomies [1]. A confirmatory diagnosis of choledocholithiasis is made using advanced imaging, including magnetic resonance cholangiopancreatography and endoscopic retrograde ...
openaire   +6 more sources

lncRNA RP11-147L13.8 suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC

Molecular Therapy: Oncolytics, 2021
Long non-coding RNAs (lncRNAs) have been identified as critical contributors in tumor progression for many types of cancer. However, their functions in gallbladder cancer (GBC) have not been systematically clarified.
Bohao Zheng, Jiwen Wang, Kun Fan, Wentao Sun, Wenze Wan, Zhihui Gao, Xiaojian Ni, Dexiang Zhang, Xiaoling Ni, Tao Suo, Han Liu, Houbao Liu, Sheng Shen   +12 more
doaj