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The Lancet, 2021
Biliary tract cancers, including intrahepatic, perihilar, and distal cholangiocarcinoma as well as gallbladder cancer, are low-incidence malignancies in most high-income countries, but represent a major health problem in endemic areas; moreover, the incidence of intrahepatic cholangiocarcinoma is rising globally. Surgery is the cornerstone of cure; the
Juan W, Valle +4 more
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Biliary tract cancers, including intrahepatic, perihilar, and distal cholangiocarcinoma as well as gallbladder cancer, are low-incidence malignancies in most high-income countries, but represent a major health problem in endemic areas; moreover, the incidence of intrahepatic cholangiocarcinoma is rising globally. Surgery is the cornerstone of cure; the
Juan W, Valle +4 more
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Current Opinion in Gastroenterology, 1997
Cholangiocarcinomas are malignant tumors that arise from the epithelium of the intrahepatic or extrahepatic bile ducts. Cholangiocarcinomas are rare compared with hepatocellular carcinoma, comprising less than 10% of primary malignancies of the liver [1].
N Joseph Espat, Jean-Nicolas Vauthey
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Cholangiocarcinomas are malignant tumors that arise from the epithelium of the intrahepatic or extrahepatic bile ducts. Cholangiocarcinomas are rare compared with hepatocellular carcinoma, comprising less than 10% of primary malignancies of the liver [1].
N Joseph Espat, Jean-Nicolas Vauthey
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Current Opinion in Gastroenterology, 2001
Advances in cellular and molecular biology of extrahepatic cholangiocarcinoma and gallbladder adenocarcinoma are providing innovative means for the diagnosis and treatment of biliary tract cancer. Similarly, refinements in noninvasive studies--including helical computed tomography, magnetic resonance cholangiopancreatography, and endoscopic ...
E K, Abdalla, J N, Vauthey
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Advances in cellular and molecular biology of extrahepatic cholangiocarcinoma and gallbladder adenocarcinoma are providing innovative means for the diagnosis and treatment of biliary tract cancer. Similarly, refinements in noninvasive studies--including helical computed tomography, magnetic resonance cholangiopancreatography, and endoscopic ...
E K, Abdalla, J N, Vauthey
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New England Journal of Medicine, 1999
In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually.1 Biliary tract cancer is the second most common primary hepatobiliary cancer, after hepatocellular cancer. Approximately 7500 new cases of biliary tract cancer are diagnosed per year; about 5000 of these are gallbladder cancer, and between 2000
P C, de Groen +4 more
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In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually.1 Biliary tract cancer is the second most common primary hepatobiliary cancer, after hepatocellular cancer. Approximately 7500 new cases of biliary tract cancer are diagnosed per year; about 5000 of these are gallbladder cancer, and between 2000
P C, de Groen +4 more
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Current Opinion in Gastroenterology, 1999
Recent advances in the molecular and cellular biology, diagnosis, and treatment of biliary tract cancer are reviewed. Several studies have delineated the molecular and cellular biology of cholangiocarcinoma and gallbladder carcinoma. Hepatocyte growth factor seems to be mitogenic to gallbladder carcinoma, and its inhibition may have a therapeutic role ...
J A, Ehrenfried, J N, Vauthey
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Recent advances in the molecular and cellular biology, diagnosis, and treatment of biliary tract cancer are reviewed. Several studies have delineated the molecular and cellular biology of cholangiocarcinoma and gallbladder carcinoma. Hepatocyte growth factor seems to be mitogenic to gallbladder carcinoma, and its inhibition may have a therapeutic role ...
J A, Ehrenfried, J N, Vauthey
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Current Opinion in Gastroenterology, 2000
Investigation into the molecular and cellular biology of carcinogenesis continues to elucidate potential mechanisms for the initiation and progression of biliary tract cancer. The potential role of cell cycle regulators, such as Fas ligand, has been examined in the etiology of bile duct carcinoma.
J N, Cormier, J N, Vauthey
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Investigation into the molecular and cellular biology of carcinogenesis continues to elucidate potential mechanisms for the initiation and progression of biliary tract cancer. The potential role of cell cycle regulators, such as Fas ligand, has been examined in the etiology of bile duct carcinoma.
J N, Cormier, J N, Vauthey
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Radiotherapy for Biliary Tract Cancers
Seminars in Radiation Oncology, 2018Biliary tract cancers (BTCs), including intrahepatic, perihilar and distal cholangiocarcinomas, and gallbladder cancers, are a heterogeneous cohort of tumors that tend to present with advanced stage and with high rates of recurrence after surgical resection.
Florence K, Keane +2 more
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Advanced Biliary Tract Cancers
American Society of Clinical Oncology Educational Book, 2012Overview: Single-agent management of metastatic biliary tract cancers with 5-fluorouracil (5-FU) or gemcitabine has shown limited efficacy, although 5-FU has been shown to be more effective than best supportive care alone. An analysis of phase II trials has suggested that platinums enhanced the efficacy of single-agent fluoropyrimidines. In a phase III
Laura Williams, Goff, Jordan D, Berlin
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Current Opinion in Gastroenterology, 1995
Biliary tract cancer is a rare cancer in most parts of the world, but it is relatively common in some countries and ethnic groups, such as Japan, Central and South America, eastern Europe and in American Indians, and Hispanics. In some countries, such as Japan, Sweden, Finland and Italy, the age adjusted mortality of biliary tract cancer has been ...
Jean-Nicolas Vauthey, Paul Dudrick
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Biliary tract cancer is a rare cancer in most parts of the world, but it is relatively common in some countries and ethnic groups, such as Japan, Central and South America, eastern Europe and in American Indians, and Hispanics. In some countries, such as Japan, Sweden, Finland and Italy, the age adjusted mortality of biliary tract cancer has been ...
Jean-Nicolas Vauthey, Paul Dudrick
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2006
AbstractThis chapter reviews the epidemiology of biliary tract cancer. Many etiologic leads for biliary tract cancer have come from clinical observations, autopsy series, and descriptive epidemiologic studies. While a significant fraction of these tumors are related to gallstones (cholelithiasis), information on other risk factors is limited, due to ...
ANN W. HSING +3 more
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AbstractThis chapter reviews the epidemiology of biliary tract cancer. Many etiologic leads for biliary tract cancer have come from clinical observations, autopsy series, and descriptive epidemiologic studies. While a significant fraction of these tumors are related to gallstones (cholelithiasis), information on other risk factors is limited, due to ...
ANN W. HSING +3 more
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