Results 91 to 100 of about 20,671 (222)
Should PNPO Deficiency Be Treated In Utero? Clinical Findings From Prenatal Pyridoxine Therapy
JIMD Reports, Volume 67, Issue 3, May 2026.ABSTRACT Pyridox(am)ine‐5′‐phosphate oxidase (PNPO) deficiency is characterized by early‐onset epileptic encephalopathy refractory to standard antiseizure medications. It is caused by variants in the PNPO gene, resulting in deficient PNPO enzyme activity, which normally converts pyridoxine‐5′‐phosphate and pyridoxamine‐5′‐phosphate (two vitamers of ...
Chloé de Puyraimond +10 more
wiley +1 more source
Basic and applied features of multicopper oxidases, CueO, bilirubin oxidase, and laccase
The Chemical Record, 2007 AbstractMulticopper oxidases (MCOs) such as CueO, bilirubin oxidase, and laccase contain four Cu centers, type 1 Cu, type II Cu, and a pair of type III Cu's in a protein molecule consisting of three domains with homologous structure to cupredoxin containing only type I Cu. Type I Cu mediates electron transfer between the substrate and the trinuclear Cu
Takeshi, Sakurai, Kunishige, Kataoka
openaire +2 more sources
Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 5, May 2026.We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu +8 more
wiley +1 more source
Nano‐Enabled Toxicity of Pharmaceutical Excipients
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 3, May/June 2026.Excipients regarded as safe in bulk form may become toxic once incorporated into nanocarriers. This review raises awareness of nano‐enabled toxicity and highlights analytical tools and safer alternative excipients to support risk‐mitigated nanomedicine development.
Ilaria Polidori +2 more
wiley +1 more source
Development Of A Biofuel Cell Cathode Based On Immobolized Enzymes And Carbon Nanotube (CNT) For Oxygen Reduction Reactions [PDF]
, 2014 Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2014Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2014Dünya ekonomisinin sürekli gelişmesi ile birlikte ortaya çıkan en büyük sorun ...
Dzhabarly, Ilyas
core
Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix +5 more
wiley +1 more source
Signal Amplification of Self-Potential Biosensor for Glucose Monitoring
International Journal of Electrochemical Science, 2015 A self-powered electrochemical sensor (SPS) has been designed for sensitive detection of glucose based on the glucose oxidase (GOD)/polyvinyl ferrocene (PVF)/ poly(diallyldimethylammonium chloride) (PDDA -reduced graphene oxide (RGO)/glassy carbon ...
Jingyi Chen +5 more
doaj +1 more source
Bilirubin is independently associated with oxidized LDL levels in young obese patients [PDF]
, 2015 BACKGROUND: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored.
Aires, L. +13 more
core +2 more sources
Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond
Advanced Science, Volume 13, Issue 23, 23 April 2026.Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi +4 more
wiley +1 more source