Results 31 to 40 of about 20,671 (222)
Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats. [PDF]
, 2005 We investigated a possible beneficial role for bilirubin, one of the products of heme degradation by the cytoprotective enzyme heme oxygenase-1 in counteracting Escherichia coli endotoxin-mediated toxicity.
A. Almolki +12 more
core +2 more sources
The effect of bilirubin oxidase on serum bilirubin.
Kanzo, 1987 Myrothecium verrucaria MT-1により産生されるビリルビンオキシダーゼ(EC 1,3,3,5)について,本稿ではin vivoおよびin vitroにおける本物質の酵素活性を確認した.血清ビリルビンはこの酵素によりビリベルジンとなり,その大部分はさらに水溶性ジアゾ反応陰性の酸化物に変化した.この酸化物の排泄経路を認べるために14Cビリルビンをビリルビンオキシダーゼにより酸化して14Cでラベルされた酸化物を作り,これをラットに静注し,尿・胆汁中の放射能を測定した.酸化物は尿・胆汁中に速やかに排泄され,特に尿中への排泄が多かった.安全性の確認が必要ではあるが,ビリルビンオキシダーゼは新生児黄疸等の減黄治療に応用し得ると考えられた.
Haruhiko YOSHIDA +5 more
openaire +2 more sources
Measurement of direct bilirubin by use of bilirubin oxidase.
Clinical Chemistry, 1987 Abstract We developed an enzymatic method for measuring direct-reacting bilirubin (DBIL) in serum. At pH 4.5, bilirubin oxidase (BOX) oxidizes mono-conjugated bilirubin, di-conjugated bilirubin, and most of the delta-bilirubin to biliverdin.
B T, Doumas +3 more
openaire +2 more sources
Enzymatic assay for conjugated bilirubin (Bc) in serum using bilirubin oxidase (BOD) [PDF]
Journal of Clinical Laboratory Analysis, 1999 We described an automated enzymatic assay for conjugated bilirubin (Bc) in serum using the Iatro D-Bil kit, with bilirubin oxidase (EC 1.3.3.5 BOD) from Myrothecium species. The specificity of the enzyme in the Iatro D-Bil kit was examined by analyzing unconjugated bilirubin (Bu), delta bilirubin (Bdelta), and Bc with high-performance liquid ...
S, Kimura +4 more
openaire +2 more sources
Biotechnology & Biotechnological Equipment, 2020 Bilirubin oxidases (BODs), which catalyze the oxidation of bilirubin to biliverdin, are multi-copper oxidases that can be used in clinical diagnoses. Given their different reported enzymatic characterizations from laccases, BODs have gained considerable ...
Huijuan Feng +9 more
doaj +1 more source
The Development of a Direct Homologous Radioimmunoassay for Serum Cortisol [PDF]
, 1981 Peer ...
Giesemann, G. +4 more
core +2 more sources
Electrochemistry, 2020 Nanoporous gold fabricated via anodization in a buffer solution comprising potassium chloride served as an effective scaffold for the direct electron transfer-type bioelectrocatalysis of bilirubin oxidase from Myrothecium verrucaria (BOD).
Masahiro MIYATA +3 more
doaj +1 more source
Biomedicines, 2021 Liver failure is associated with increased levels of brain aromatic amino acids (AAAs), whose transport across the blood–brain barrier (BBB) is mainly mediated by L-amino acid transporter 1 (LAT1). We aimed to investigate whether liver failure induced by
Xiaoke Zheng +9 more
doaj +1 more source
Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]
, 2015 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti +9 more
core +2 more sources
2型糖尿病患者における血清ビリルビン値とアルブミン尿の進展および腎機能低下との関連に関する研究 [PDF]
, 2014 博士（医学） 乙第2834号， 著者名：Kiwako Toya・Tetsuya Babazono・Ko Hanai・Yasuko Uchigata，タイトル：Association of serum bilirubin levels with development and progression of albuminuria, and decline in estimated glomerular filtration rate in patients with type 2 diabetes ...
東谷, 紀和子
core +2 more sources