Results 31 to 40 of about 50,489 (260)

Comprehensive representation of feasible combinations of alternatives for dynamic production planning using Zero-Suppressed Binary Decision Diagram

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
The goal of the production-planning problem is to find the optimal solution from combinations that satisfy constraints. Traditionally, production-planning problems have been treated separately, due to the problem size and complex constraints, whereas the
Keita TAKAHASHI   +2 more
doaj   +1 more source

Hardware implementation of Boolean functions based on the automaton model

open access: yesInformatika, 2023
Objectives. Currently, electronic control devices are increasingly being introduced into various household and production products. Microcontrollers of a wide variety of configurations are widely used as such devices.
A. A. Butov
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Lattice-Valued Binary Decision Diagrams [PDF]

open access: yes, 2010
This work introduces a new data structure, called Lattice-Valued Binary Decision Diagrams (or LVBDD for short), for the compact representation and manipulation of functions of the form θ : 2P → L, where P is a finite set of Boolean propositions and L is a finite distributive lattice.
Geeraerts, Gilles   +4 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

A parallel algorithm for constructing binary decision diagrams [PDF]

open access: yesProceedings., 1990 IEEE International Conference on Computer Design: VLSI in Computers and Processors, 2002
A parallel algorithm for constructing binary decision diagrams is described. The algorithms treats binary decision graphs as minimal finite automata. The automation for a Boolean function with AND as its main operation (OR operation) is obtained by forming the intersection (union) of the regular sets associated with its operands.
Shinji Kimura, Edmund M. Clarke
openaire   +1 more source

Efficient Mincuts Identification for Phased-Mission Systems

open access: yesIEEE Access, 2020
Fault Tree is an important model for reliability and safety assessment. The analysis performed on a fault tree can be either qualitative or quantitative. Both types of analyses may involve identifying minimal cut sets (MCS) or mincuts, each of which is a
Yuchang Mo   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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