Results 51 to 60 of about 3,800,996 (288)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Arc Routing Based on the Zero-Suppressed Binary Decision Diagram

, 2020
A wide range of problems in operations research falls under arc routing problems, a domain which focuses on arc or edge features rather than node or vertex attributes. The undirected rural postman problem is a well-known problem in arc routing that seeks
Florian Sikora, Tan, Renzo Roel P, See, Kyle Stephen S., Tan, Renzo Roel P., Renzo Roel P. Tan, Kyle Stephen S. See, Sikora, Florian, Kazushi Ikeda, Ikeda, Kazushi, See, Kyle Stephen S   +9 more
core   +1 more source

A Synthesis Method Based on Multi-Stage Optimization for Power-Efficient Integrated Optical Logic Circuits [PDF]

, 2021
Optical logic circuits based on integrated nanophotonics attract significant interest due to their ultra-high-speed operation. However, the power dissipation of conventional optical logic circuits is exponential to the number of inputs of target logic ...
MATSUO, Ryosuke, ONODERA, Hidetoshi, NOTOMI, Masaya, SHIOMI, Jun, ISHIHARA, Tohru, SHINYA, Akihiko   +5 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Average Path Length of Binary Decision Diagrams [PDF]

IEEE Transactions on Computers, 2005
The traditional problem in binary decision diagrams (BDDs) has been to minimize the number of nodes since this reduces the memory needed to store the BDD. Recently, a new problem has emerged: minimizing the average path length (APL). APL is a measure of the time needed to evaluate the function by applying a sequence of variable values. It is of special
Sasao, Tsutomu, Matsuura, Munehiro, Butler, Jon T.   +2 more
openaire   +3 more sources

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Network Simplification and K-Terminal Reliability Evaluation of Sensor-Cloud Systems

IEEE Access, 2020
The sensor-cloud system (SCS) integrates sensors, sensor networks, and cloud for managing sensors, collecting and processing data, and decision-making based on data processed.
Yuchang Mo, Min Liang, Liudong Xing, Jinping Liao, Xuli Liu   +4 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Dynamic Euler Diagram Drawing [PDF]

, 2004
In this paper we describe a method to lay out a graph enhanced Euler diagram so that it looks similar to a previously drawn graph enhanced Euler diagram. This task is non-trivial when the underlying structures of the diagrams differ.
Rodgers, Peter, Mutton, Paul, Flower, Jean   +2 more
core   +1 more source

Quantitative fault tree analysis using binary decision diagrams

, 1996
Quantitative fault tree analysis using binary decision ...
J.D. Andrews (7120562), Roslyn M. Sinnamon (7119437)   +1 more
core   +6 more sources