Results 21 to 30 of about 28,422 (257)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The impact of binary stars in the determination of the total mass of stellar system. [PDF]

, 2022
Binary stars play a very important role in the dynamics of stellar systems such as star clusters. After a detailed analysis of binary classification, formation mechanisms and both fundamental parameters and distributions, the impact of binaries in the
Pianta, Camilla
core  

FM stars II: a Fourier view of pulsating binary stars - determining binary orbital parameters photometrically for highly eccentric cases

, 2015
Continuous and precise space-based photometry has made it possible to measure the orbital frequency modulation of pulsating stars in binary systems with extremely high precision over long time spans.
Kurtz, Donald W., Murphy, Simon J., Kurtz, Donald Wayne, Murphy, S. J., Shibahashi, Hiromoto, Shibahashi, H.   +5 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

New periodic variable stars coincident with ROSAT sources discovered using SuperWASP [PDF]

, 2007
We present optical lightcurves of 428 periodic variable stars coincident with ROSAT X-ray sources, detected using the first run of the SuperWASP photometric survey. Only 68 of these were previously recognised as periodic variables.
West, Richard G., Pollacco, Don, M. Gallaway, Street, R. A., Horne, K. (Keith), Kane, S. R., Christian, Damian Joseph, D. J. Christian (7603835), Hellier, Coel, Enoch, B., Nicholas, J. P., D. Pollacco (7603205), Irwin, J., Skillen, I., B. Enoch (7603838), West, R. G., R. A. Street, D. J. Christian, T. A. Lister (7603856), Irwin, Jonathan, K. Horne, Ryans, R., C. A. Haswell, D. M. Wilson (2428792), Wilson, D. M., Christian, D. J., J. P. Nicholas (7614728), S. R. Kane (7603853), S. R. Kane, Haswell, C. A., J. P. Nicholas, B. Enoch, C. Hellier (7603562), Norton, A. J., W. I. Clarkson, R. G. West, Lister, T. A., W. I. Clarkson (7612619), West, R .G., J. Irwin, Gallaway, M., T. A. Lister, Collier Cameron A (7614731), Pollacco, D., Parley, N., K. Horne (7603850), R. Ryans, C. A. Haswell (7603844), P. J. Wheatley (7590065), Hellier, C., Norton, Andrew J., R. Ryans (7612838), N. Parley, D. M. Wilson, Parley, N. R., I. Skillen (7601975), A. J. Norton (7603859), Horne, Keith Douglas, Horne, K. D., I. Skillen, R. G. West (7602272), A. Collier Cameron, J. Irwin (7606340), P. J. Wheatley, C. Hellier, R. A. Street (7603868), M. Gallaway (7614725), N. Parley (7603862), Cameron, Andrew Collier, Collier Cameron, A., Clarkson, W. I., Kane, Sharad R., Wheatley, P. J., A. J. Norton, Wilson, D. M. (David M.), D. Pollacco   +75 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source