Results 41 to 50 of about 28,422 (257)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Binary Statistics and Star Formation [PDF]

Astrophysics and Space Science, 1984
AbstractBinary statistics, in particular the distributions of mass ratios and orbital periods, are reviewed in an attempt to obtain clues to possible star formation and cloud fragmentation processes. Various observational selection effects which hamper the establishment of the true distributions are discussed.
openaire   +1 more source

The Evolution of Compact Binary Star Systems [PDF]

Living Reviews in Relativity, 2006
AbstractWe review the formation and evolution of compact binary stars consisting of white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and BHs are thought to be the primary astrophysical sources of gravitational waves (GWs) within the frequency band of ground-based detectors, while compact binaries of WDs are important sources ...
Yungelson, Lev R., Postnov Konstantin A.
openaire   +10 more sources

Enhanced magnetic activity in rapidly rotating binary stars

Stellar activity is fundamental to stellar evolution and the formation and habitability of exoplanets. Magnetic surface activity is driven by the interaction between convective motions and rotation in cool stars, resulting in a dynamo process.
Gizon, Laurent, Gehan, Charlotte, Nordhaus, Jason, Tayar, Jamie, Chen, Yajie, Gaulme, Patrick, Ting, Yuan-Sen, Murphy, Simon J., Bedding, Timothy R., Han, Zhanwen, Cameron, Robert H., Hekker, Saskia, Yu, Jie, Bi, Shaolan, Bazot, Michäel   +14 more
core   +1 more source

Observations of binary stars with the differential speckle survey instrument. IV. Observations of Kepler, CoRoT, and Hipparcos stars from the Gemini North Telescope

, 2012
We present the results of 71 speckle observations of binary and unresolved stars, most of which were observed with the DSSI speckle camera at the Gemini North Telescope in 2012 July. The main purpose of the run was to obtain diffraction-limited images of
Everett, Mark E., Ciardi, David R., Horch, Elliott P., Howell, Steve B.   +3 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Asteroseismology of Close Binary Stars [PDF]

Proceedings of the International Astronomical Union, 2006
AbstractIn this review paper, we summarise the goals of asteroseismic studies of close binary stars. We first briefly recall the basic principles of asteroseismology, and highlight how the binarity of a star can be an asset, but also a complication, for the interpretation of the stellar oscillations.
openaire   +3 more sources