Results 41 to 50 of about 14,064 (261)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Gravity darkening in binary stars [PDF]

Astronomy & Astrophysics, 2012
Context.Interpretation of light curves of many types of binary stars requires the inclusion of the (cor)relation between surface brightness and local effective gravity. Until recently, this correlation has always been modeled by a power law relating the flux or the effective temperature and the effective gravity, namely T_eff α g_eff^β. Aims.
Lara, Francisco Espinosa, Rieutord, Michel   +1 more
openaire   +2 more sources

Orbits of Twelve Multiple Stars

The Astronomical Journal
Inner and outer orbits in 12 hierarchical stellar systems are determined using high-resolution speckle imaging, radial velocities, or both. Masses and fluxes of the components are estimated. The Hipparcos numbers of the main stars are 7111, 12912, 17895,
Andrei Tokovinin
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Eclipse Depth Variations in Seven Eclipsing Binaries as Observed by KELT and TESS

The Astronomical Journal
A set of eclipsing binary systems exhibit a changing inclination over time due to the gravitational influence of a third stellar companion. These changing inclinations manifest in photometric observations over time as eclipse depth variations.
Anna C. Baum, Joshua Pepper, James R. A. Davenport, Steve B. Howell   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Contact-binary Evolution with Energy Transfer and Saturated Magnetic Braking

The Astrophysical Journal
The evolution of low-mass contact binaries is influenced by angular momentum loss, mass and energy transfer (ET), and the nuclear evolution of the components.
Matthias Fabry, Andrej Prša
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Binary Statistics and Star Formation [PDF]

Astrophysics and Space Science, 1984
AbstractBinary statistics, in particular the distributions of mass ratios and orbital periods, are reviewed in an attempt to obtain clues to possible star formation and cloud fragmentation processes. Various observational selection effects which hamper the establishment of the true distributions are discussed.
openaire   +1 more source