Results 31 to 40 of about 14,064 (261)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

TESS Photometry and LAMOST Spectroscopy of 10 Detached Eclipsing Binaries

The Astronomical Journal
This study presents a thorough analysis of 10 detached eclipsing binaries that contain main-sequence stars. We have utilized a multifaceted approach, incorporating data from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST), TESS ...
Mengxin Wang, Hailong Yuan, Zhongrui Bai, Yiqiao Dong, Ming Zhou, Mingkuan Yang, Yuji He, Shuguo Ma, Xiaobin Zhang, Haotong Zhang   +9 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Detection of Contact Binary Candidates Observed By TESS Using the Autoencoder Neural Network

The Astronomical Journal
A contact binary may be the progenitor of a red nova that eventually produces a merger event and have a cut-off period of around 0.2 days. Therefore, a large number of contact binaries is needed to search for the progenitor of red novae and to study the ...
Xu Ding, ZhiMing Song, ChuanJun Wang, KaiFan Ji   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

TIC 290061484: A Triply Eclipsing Triple System with the Shortest Known Outer Period of 24.5 Days

The Astrophysical Journal
We have discovered a triply eclipsing triple-star system, TIC 290061484, with the shortest known outer period, P _out , of only 24.5 days. This “eclipses” the previous record set by λ Tauri at 33.02 days, which held for 68 yr.
V. B. Kostov, S. A. Rappaport, T. Borkovits, B. P. Powell, R. Gagliano, M. Omohundro, I. B. Bíró, M. Moe, S. B. Howell, T. Mitnyan, C. A. Clark, M. H. Kristiansen, I. A. Terentev, H. M. Schwengeler, A. Pál, A. Vanderburg   +15 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Coalescing binary neutron stars [PDF]

Classical and Quantum Gravity, 1999
Coalescing compact binaries with neutron star or black hole components provide the most promising sources of gravitational radiation for detection by the LIGO/VIRGO/GEO/TAMA laser interferometers now under construction. This fact has motivated several different theoretical studies of the inspiral and hydrodynamic merging of compact binaries.
Rasio, Frederic A., Shapiro, Stuart L.
openaire   +2 more sources

Spectroscopic Orbits of Subsystems in Multiple Stars. XI

The Astronomical Journal
Adding to the large radial velocity survey of nearby solar-type stars (summary in Tokovinin, 2023a), spectroscopic orbits are determined for four hierarchical systems: HIP 49442 (inner and outer periods of 164.55 days and 34 yr, respectively), HIP 55691 (
Andrei Tokovinin
doaj   +1 more source