Results 31 to 40 of about 28,422 (257)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Binary black holes from population III stars. [PDF]

, 2022
openIn this thesis I evaluate the merger rate density of binary black holes from Population III stars. This work takes into consideration different models for the stellar system's initial conditions and for the star formation rate density.
MERLI, LORENZO
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

XMM-Newton X-ray study of early type stars in the Carina OB1 association [PDF]

, 2007
<p><b>Aims:</b> X-ray properties of the stellar population in the Carina OB1 association are examined with special emphasis on early-type stars.
I. I. Antokhin, J. C. Brown, Rauw, G., G. Rauw, J.-M. Vreux, Antokhin, I. I., Antokhin, I.I., Brown, J.C., van der Hucht, K.A., Rauw, Grégor, K. A. van der Hucht, Vreux, Jean-Marie, Vreux, J.M., van der Hucht, K. A., Brown, J. C.   +14 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Coalescing binary neutron stars [PDF]

Classical and Quantum Gravity, 1999
Coalescing compact binaries with neutron star or black hole components provide the most promising sources of gravitational radiation for detection by the LIGO/VIRGO/GEO/TAMA laser interferometers now under construction. This fact has motivated several different theoretical studies of the inspiral and hydrodynamic merging of compact binaries.
Rasio, Frederic A., Shapiro, Stuart L.
openaire   +2 more sources

BinSlayer: Accurate Comparison of Binary Executables [PDF]

, 2013
As the volume of malware inexorably rises, comparison of binary code is of increasing importance to security analysts as a method of automatically classifying new malware samples; purportedly new examples of malware are frequently a simple evolution of ...
Martial Bourquin, Bourquin, Martial, Andy King, Robbins, Edward, King, Andy, Edward Robbins   +5 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Gravity darkening in binary stars [PDF]

Astronomy & Astrophysics, 2012
Context.Interpretation of light curves of many types of binary stars requires the inclusion of the (cor)relation between surface brightness and local effective gravity. Until recently, this correlation has always been modeled by a power law relating the flux or the effective temperature and the effective gravity, namely T_eff α g_eff^β. Aims.
Lara, Francisco Espinosa, Rieutord, Michel   +1 more
openaire   +2 more sources

Probing the composition of sub-millisecond rotating compact stars by r-modes instability

, 2012
We investigate the implications of the r-modes instability on the composition of a compact star rotating at a sub-millisecond period. In particular, the only viable astrophysical scenario for such an object, wich might present inside the Low Mass X-ray ...
Giuseppe Pagliara, Drago, Alessandro, Alessandro Drago, Pagliara, Giuseppe   +3 more
core   +1 more source