Results 31 to 40 of about 13,554 (261)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Detection of Contact Binary Candidates Observed By TESS Using the Autoencoder Neural Network

The Astronomical Journal
A contact binary may be the progenitor of a red nova that eventually produces a merger event and have a cut-off period of around 0.2 days. Therefore, a large number of contact binaries is needed to search for the progenitor of red novae and to study the ...
Xu Ding, ZhiMing Song, ChuanJun Wang, KaiFan Ji   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

TIC 290061484: A Triply Eclipsing Triple System with the Shortest Known Outer Period of 24.5 Days

The Astrophysical Journal
We have discovered a triply eclipsing triple-star system, TIC 290061484, with the shortest known outer period, P _out , of only 24.5 days. This “eclipses” the previous record set by λ Tauri at 33.02 days, which held for 68 yr.
V. B. Kostov, S. A. Rappaport, T. Borkovits, B. P. Powell, R. Gagliano, M. Omohundro, I. B. Bíró, M. Moe, S. B. Howell, T. Mitnyan, C. A. Clark, M. H. Kristiansen, I. A. Terentev, H. M. Schwengeler, A. Pál, A. Vanderburg   +15 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Spectroscopic Orbits of Subsystems in Multiple Stars. XI

The Astronomical Journal
Adding to the large radial velocity survey of nearby solar-type stars (summary in Tokovinin, 2023a), spectroscopic orbits are determined for four hierarchical systems: HIP 49442 (inner and outer periods of 164.55 days and 34 yr, respectively), HIP 55691 (
Andrei Tokovinin
doaj   +1 more source

Supergiant Binary Stars

The Astrophysical Journal, 1974
It is pointed out that the energy radiated by HD 101584 (F2e Iap) at IR frequencies cannot be convincingly explained by thermal reradiation from atmospheric grains. It is theorized that this energy emission can be explained by assuming that the F supergiant has an M supergiant companion responsible for IR radiation.
Roberta M. Humphreys, E. P. Ney
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Orbits of Twelve Multiple Stars

The Astronomical Journal
Inner and outer orbits in 12 hierarchical stellar systems are determined using high-resolution speckle imaging, radial velocities, or both. Masses and fluxes of the components are estimated. The Hipparcos numbers of the main stars are 7111, 12912, 17895,
Andrei Tokovinin
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source