Results 91 to 100 of about 2,748,278 (304)
Application of CoLD-CoP to Detecting Competitively and Cooperatively Binding Ligands
BiomoleculesNMR utilization in fragment-based drug discovery requires techniques to detect weakly binding fragments and to subsequently identify cooperatively binding fragments. Such cooperatively binding fragments can then be optimized or linked in order to develop
Shiva V. Patnala +2 more
doaj +1 more source
NAC and DTT promote TGF-β1 monomer formation: demonstration of competitive binding
Journal of Inflammation, 2006 TGF-β plays an important role in the genesis and progression of pulmonary fibrosis. We sought to determine the role of mononuclear phagocytes in the activation of TGF-β and found that freshly isolated peripheral blood monocytes spontaneously released TGF-
Frambach Gwyn +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Competitive CarboxylateSilicate Binding at Iron Oxyhydroxide Surfaces
, 2021 Dissolved silicate ions in wet and dry soils can determine the fate of organic contaminants via competitive binding. While fundamental surface science studies have advanced knowledge of binding in competitive systems, little is still known about the ...
Khalil Hanna +7 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Chemiluminescent detection of competitive inhibition of LBP binding to CD14 by phage clones.
, 2014 A. Non-luminescent particles indicated clones with competitive binding capacity. B. Number of single clones corresponding to the chemiluminescence plate labels and their competitive inhibition status.
Fu-yun Ji (598404) +6 more
core +1 more source
Functional Methods for Studying Sperm–Zona Pellucida Interaction in Mammals
Methods and ProtocolsThe initial molecular events mediating mammalian sperm binding to the zona pellucida (ZP) of the oocyte are highly complex and still not fully elucidated.
Natalie Zelenkova +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Spatial feature binding and learning in competitive neural layer architectures
, 2000 Wersing H. Spatial feature binding and learning in competitive neural layer architectures.
Wersing, Heiko
core
, 1997 The human osteocalcin gene is transcriptionally repressed by glucocorticoids. A specific binding element for the glucocorticoid receptor (GR) overlapping the TATA box of the human osteocalcin promoter has previously been identified. In the present study,
Gustafsson, JA +2 more
core +1 more source