Results 81 to 90 of about 2,748,278 (304)

Competitive binding assays of the Cry8 toxin and toxin-DNA complex using the BBMVs from the target larvae.

open access: yes, 2013
A. Competitive binding of the Cry8Ea1 toxin and Cry8Ea1 toxin-DNA complex with the BBMVs of H. parallela larvae. B. Competitive binding of the Cry8Ca2 toxin and Cry8Ca2 toxin-DNA complex with the BBMVs of A. corpulenta larvae.
Bingjie Ai (492597)   +4 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Competitive binding of candidate ligands with 1-NPN and recombinant FoccCSP protein.

open access: yes, 2015
Competitive binding of candidate ligands with 1-NPN and recombinant FoccCSP protein.
Zhong-Ren Lei (688118)   +1 more
core   +1 more source

Studies on the Binding of Carboxypeptidase A and Several Competitive Inhibitors

open access: yesJournal of Biological Chemistry, 1962
Several spectral changes have been reported to be related to changes in bonding or other factors in the environment of the side chains of aromatic amino acid residues (l-lo). It would then be expected that on addition of a competitive inhibitor to an enzyme solution, a change in the spectrum of the enzyme could be observed, if aromatic amino acid ...
H, FUJIOKA, K, IMAHORI
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Study of competitive binding of enantiomers to protein by affinity capillary electrochromatography

open access: yes, 2002
Affinity capillary electrochromatography (CEC) with zonal elution method was used to probe the competitive interactions of enantiomers with protein. In this approach, a known concentration of a competing agent is continuously applied to a CEC column with
Lei, ZD   +5 more
core  

Competitive binding of two drugs for a single binding site on albumin: a circular dichroic study

open access: yes, 1973
Sulphaethidole has been previously shown to have two classes of binding site on bovine serum albumin (BSA). Only the primary binding site is capable of inducing optical activity in the drug.
J H Perrin, D A Nelson
core   +1 more source

Kinetics of Competitive Binding with Application to Thrombin Complexes

open access: yesAnalytical Biochemistry, 1997
The kinetics of competitive binding is treated analytically, allowing the rate constants to be determined accurately from simple experiments. The method is especially suited to situations where traditional approximations and numerical integration fail, e.g., when the dissociation constants are small or when the concentration of one receptor cannot be ...
W J, Wedemeyer   +2 more
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Ligand-binding experiments.

open access: yes, 2015
(A) Binding curve and relative Scatchard plot. (B, C, D, E) Competitive binding curves of different ligands to the MvitGOBP1. (F, G, H, I) Competitive binding curves of different ligands to the MvitGOBP2.
Kaiyu Liu (309766)   +8 more
core   +1 more source

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