Results 81 to 90 of about 2,617,421 (301)

Study of competitive binding of enantiomers to protein by affinity capillary electrochromatography

, 2002
Affinity capillary electrochromatography (CEC) with zonal elution method was used to probe the competitive interactions of enantiomers with protein. In this approach, a known concentration of a competing agent is continuously applied to a CEC column with
Lei, ZD, Zou, HF, Liu, Z, Wu, RN, Ni, JY, Ye, ML   +5 more
core  

Replication Data for: Non-separable Preferences in the Statistical Analysis of Roll Call Votes

Conventional multidimensional statistical models of roll call votes assume that legislators' preferences are additively separable over dimensions. In this article, we introduce an item response model of roll call votes that allows for non-separability ...
Stoetzer, Lukas F., Binding, Garret
core   +1 more source

Conformational dynamics of the tetracycline-binding aptamer [PDF]

, 2011
The conformational dynamics induced by ligand binding to the tetracycline-binding aptamer is monitored via stopped-flow fluorescence spectroscopy and time-correlated single photon counting experiments.
Weigand, Julia E., Josef Wachtveitl, Suess, Beatrix, Ute Förster, Trojanowski, Peter, Peter Trojanowski, Julia E. Weigand, Förster, Ute, Wachtveitl, Josef, Süß, Beatrix, Beatrix Suess   +10 more
core   +1 more source

Studies on the Binding of Carboxypeptidase A and Several Competitive Inhibitors

Journal of Biological Chemistry, 1962
Several spectral changes have been reported to be related to changes in bonding or other factors in the environment of the side chains of aromatic amino acid residues (l-lo). It would then be expected that on addition of a competitive inhibitor to an enzyme solution, a change in the spectrum of the enzyme could be observed, if aromatic amino acid ...
H, FUJIOKA, K, IMAHORI
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Deutsches Staatsrecht | Erster Band: Die Grundlagen des deutschen Staates und die Reichsgewalt. Systematisches Handbuch der Deutschen Rechtswissenschaft. Fünfte Abtheilung, erster Theil. Hrsg. von Karl Binding

, 2023
Das vorliegende Werk erschien als fünfter Teil des von Karl Binding herausgegebenen Werkes »Systematisches Handbuch der Deutschen Rechtswissenschaft« und ist auf zwei Bände ausgelegt.
Albert Haenel
core   +1 more source

Application of CoLD-CoP to Detecting Competitively and Cooperatively Binding Ligands

Biomolecules
NMR utilization in fragment-based drug discovery requires techniques to detect weakly binding fragments and to subsequently identify cooperatively binding fragments. Such cooperatively binding fragments can then be optimized or linked in order to develop
Shiva V. Patnala, Roberto Robles, David A. Snyder   +2 more
doaj   +1 more source

Kinetics of Competitive Binding with Application to Thrombin Complexes

Analytical Biochemistry, 1997
The kinetics of competitive binding is treated analytically, allowing the rate constants to be determined accurately from simple experiments. The method is especially suited to situations where traditional approximations and numerical integration fail, e.g., when the dissociation constants are small or when the concentration of one receptor cannot be ...
W J, Wedemeyer, R W, Ashton, H A, Scheraga   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

NAC and DTT promote TGF-β1 monomer formation: demonstration of competitive binding

Journal of Inflammation, 2006
TGF-β plays an important role in the genesis and progression of pulmonary fibrosis. We sought to determine the role of mononuclear phagocytes in the activation of TGF-β and found that freshly isolated peripheral blood monocytes spontaneously released TGF-
Frambach Gwyn, Hunter Melissa, Montague Christine R, Lichtenberger Frank J, Marsh Clay B   +4 more
doaj   +1 more source