Results 61 to 70 of about 2,748,278 (304)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The key to 2,6-dichloro-1,4-benzoquinone reproductive toxicity and green tea detoxification: Covalent binding and competitive binding

Ecotoxicology and Environmental Safety
Halobenzoquinones (HBQs) are ubiquitous disinfection by-products (DBPs) in chlorinated drinking water with various health risks including reproductive toxicity, while the potential mechanisms are still unclear.
Meixian Liu, Zhiyuan Ning, Yong Cheng, Zhiyuan Zheng, Xiaoxue Yang, Ting Zheng, Na Li, Jian-Lin Wu   +7 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

CLASP-mediated competitive binding in protein condensates directs microtubule growth

Nature Communications
Microtubule organization in cells relies on targeting mechanisms. Cytoplasmic linker proteins (CLIPs) and CLIP-associated proteins (CLASPs) are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here, we reveal that
Xuanyan Jia, Leishu Lin, Siqi Guo, Lulu Zhou, Gaowei Jin, Jiayuan Dong, Jinman Xiao, Xingqiao Xie, Yiming Li, Sicong He, Zhiyi Wei, Cong Yu   +11 more
doaj   +1 more source

Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II

Pharmaceuticals
Background/Objectives: DPP4 is an enzyme with multiple natural substrates and probable involvement in various mechanisms. It constitutes a drug target for the treatment of diabetes II, although, also related to other disorders.
Dionysia Amanatidou, Phaedra Eleftheriou, Anthi Petrou, Athina Geronikaki, Theodoros Lialiaris   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Pasteurellaceae ComE1 proteins combine the properties of Fibronectin Adhesins and DNA binding competence proteins [PDF]

, 2008
A novel fibronectin-binding protein from Pasteurella multocida (PM1665) that binds to the fibronectin type III9-10 modules via two helix-hairpin-helix motifs has recently been described [1].
Langford, P.R., Andrew N Rycroft, Rycroft, AN, Bereswill, S., Bossé Janine T., Giles Robertson, Rycroft, A.N., Janine T Bossé, Henderson Brian, Henderson, B., Nair, SP, Lisa M Mullen, Nair Sean P., Bossé, J.T., Robertson, Giles, Henderson, B, Langford, PR, Brian Henderson, Mullen, LM, Mullen, Lisa M., Bosse, JT, Rycroft Andrew N., Ward, J.M., Nair, S.P., Langford Paul R., Sean P Nair, Ward John M., Paul R Langford, Robertson, G, Ward, JM, Mullen Lisa M., Robertson Giles, John M Ward   +32 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

A Competitive Layer Model for Feature Binding and Sensory Segmentation

, 2001
Wersing H, Steil JJ, Ritter H. A Competitive Layer Model for Feature Binding and Sensory Segmentation. Neural Computation.
Wersing, Heiko, Jochen J. Steil, Ritter, Helge ; https://orcid.org/, Heiko Wersing, Steil, Jochen J., Helge Ritter   +5 more
core   +1 more source