Results 61 to 70 of about 3,754,687 (312)

IGF UPTAKE WITH COMPETITIVE BINDING IN ARTICULAR CARTILAGE [PDF]

Journal of Biological Systems, 2008
Experiments on the transport of radiolabeled Insulin-like Growth Factors (IGF-I and -II) into bovine articular cartilage show differential uptake depending on the relative proportion of IGF-I and -II. In this study, we present a mathematical model describing both the transport and competition of IGF-I and -II for binding sites represented by two ...
Zhang, Lihai, Gardiner, Bruce, Smith, David, Pivonka, Peter, Grodzinsky, Alan   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger

ACS Chemical Biology, 2014
The Pygo-BCL9 complex is a chromatin reader, facilitating β-catenin-mediated oncogenesis, and is thus emerging as a potential therapeutic target for cancer.
Thomas C. R. Miller, T. Rutherford, K. Birchall, J. Chugh, M. Fiedler, M. Bienz   +5 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MHCflurry: open-source class I MHC binding affinity prediction

bioRxiv, 2017
Machine learning prediction of the interaction between major histocompatibility complex I (MHC I) proteins and their small peptide ligands is important for vaccine design and other applications in adaptive immunity.
Tim O’Donnell, A. Rubinsteyn, M. Bonsack, A. Riemer, Uri Laserson, Jeff Hammerbacher   +5 more
semanticscholar   +1 more source

Competitive binding of chlorophyllin and proflavine to DNA

Біофізичний вісник, 2016
The effect of chlorophyllin (Chln) on the DNA-proflavine (Pf) interactions has been investigated by spectrophotometry. The absorption spectra were recorded at different DNA-to-ligand molar ratios.
А. А. Герус, Н. А. Гладковская, Е. Г. Березняк, Е. В. Духопельников   +3 more
doaj  

CLASP-mediated competitive binding in protein condensates directs microtubule growth

Nature Communications
Microtubule organization in cells relies on targeting mechanisms. Cytoplasmic linker proteins (CLIPs) and CLIP-associated proteins (CLASPs) are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here, we reveal that
Xuanyan Jia, Leishu Lin, Siqi Guo, Lulu Zhou, Gaowei Jin, Jiayuan Dong, Jinman Xiao, Xingqiao Xie, Yiming Li, Sicong He, Zhiyi Wei, Cong Yu   +11 more
doaj   +1 more source

The key to 2,6-dichloro-1,4-benzoquinone reproductive toxicity and green tea detoxification: Covalent binding and competitive binding

Ecotoxicology and Environmental Safety
Halobenzoquinones (HBQs) are ubiquitous disinfection by-products (DBPs) in chlorinated drinking water with various health risks including reproductive toxicity, while the potential mechanisms are still unclear.
Meixian Liu, Zhiyuan Ning, Yong Cheng, Zhiyuan Zheng, Xiaoxue Yang, Ting Zheng, Na Li, Jian-Lin Wu   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.

ACS Medicinal Chemistry Letters, 2018
Drugging large protein pockets is a challenge due to the need for higher molecular weight ligands, which generally possess undesirable physicochemical properties. In this communication, we highlight a strategy leveraging small molecule active site dimers
T. Siu, Michael D. Altman, Gretchen A. Baltus, M. Childers, J. Michael Ellis, H. Gunaydin, H. Hatch, Thu Ho, James P. Jewell, Brian M. Lacey, C. Lesburg, B. Pan, B. Sauvagnat, Gottfried K. Schroeder, Serena Xu   +14 more
semanticscholar   +1 more source