Results 241 to 250 of about 3,754,687 (312)

Zona Binding: Competitive Sperm-Binding Assay

2021
De Yi Liu, Ying Zhong, Zi-Na Wen
openaire   +2 more sources

Discovery of tight-binding competitive inhibitors of dipeptidyl peptidase IV.

International Journal of Biological Macromolecules, 2021
Dipeptidyl peptidase IV (DPP-IV, EC 3.4.14.5) is an abundant serine aminopeptidase that preferentially cleaves N-terminal Xaa-Pro or Xaa-Ala dipeptides from oligopeptides.
Isel Pascual Alonso, P. A. Valiente, Mario E. Valdés-Tresanco, Yarini Arrebola, Fabiola Almeida García, Lisset Díaz, Gabriel Garcia, Osmany Guirola, Daniel Pastor, Gretchen Bergado, Belinda Sánchez, J. Charli   +11 more
semanticscholar   +1 more source

Competition in drug binding and … the race to equilibrium

Fundamental & Clinical Pharmacology, 2022
AbstractBinding kinetics has become a popular topic in pharmacology due to its potential contribution to the selectivity and duration of drug action. Yet, the overall kinetic aspects of complex binding mechanisms are still merely described in terms of elaborate algebraic equations.
Georges Vauquelin, Dominique Maes
openaire   +2 more sources

Competitive binding assays for riboflavin and riboflavin-binding protein

Analytical Biochemistry, 1982
Abstract A competitive binding procedure that can be used to determine either riboflavin or riboflavin-binding protein has been developed. Riboflavin-binding protein from chicken egg white binds tightly to DEAE-cellulose while free riboflavin does not.
S E, Lotter, M S, Miller, R C, Bruch, H B, White   +3 more
openaire   +2 more sources

Competitive hapten-antibody binding: Solution of the binding equation

Journal of Theoretical Biology, 1965
Abstract The competitive binding equation which describes the reactions between two univalent homogeneous cross-reacting haptens and antibody heterogeneous with respect to equilibrium constants has been solved. The joint probability density function of equilibrium constants can be computed directly from binding measurements; no assumption about the ...
J, Wong, F, Aladjem
openaire   +2 more sources

TESTOSTERONE ASSAYS BY COMPETITIVE PROTEIN BINDING

Acta Endocrinologica, 1970
ABSTRACT A review of competitive protein binding methods for the determination of testosterone in plasma is given. The different steps discussed are: Choice of the binding protein, dilution of the protein solution, separation of the free from the bound fraction, purification of the extract and factors determining the blank.
A, Vermeulen, L, Verdonck
openaire   +2 more sources

Competitive protein binding assay of corticosterone

Journal of Steroid Biochemistry, 1972
Abstract Details of a competitive protein binding assay of corticosterone are described. The preliminary TLC separation permits simultaneous estimation of corticosterone, aldosterone and progesterone. “Unstressed” rat plasma corticosterone values were obtained between 0.3 and 9 μg/ 100 ml.
A, Spät, S, Józan
openaire   +2 more sources

Evaluation of the binding behavior of olmutinib (HM61713) with model transport protein: Insights from spectroscopic and molecular docking studies

, 2021
Olmutinib (HM61713, OMT), a novel third-generation tyrosine kinase inhibitor with good orally absorption, is able to inhibit selectively epidermal growth factor receptor mutations.
Song‐Bo Kou, Zhen‐Yi Lin, Bao-li Wang, Jie‐Hua Shi, ying-xin Liu   +4 more
semanticscholar   +1 more source

Effect of transport and competition on ligand binding

Biophysical Chemistry, 1999
We present a model to describe the physics of chemoreception in processes determined by competitive ligand binding. Our model describes the competition between various populations, such as ligands vs. blockers and receptors vs. decoys, in protein activation when diffusion is rate-determining.
C. A. CONDAT, DELSANTO, PIER PAOLO, E. RUFFINO, G. PEREGO   +3 more
openaire   +3 more sources

Cefmenoxime and Bilirubin: Competition for Albumin Binding

Pharmacology & Toxicology, 1991
Abstract:Certain drugs are known to compete with bilirubin for albumin binding; therefore, all drugs administered to neonates should be tested to determine the degree of competition. The effect of cefmenoxime on bilirubin‐albumin binding was determined by comparing the oxidation rate of free bilirubin in the presence and absence of drug.
D L, Onks, J F, Harris, A F, Robertson
openaire   +2 more sources