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Epidermal growth factor receptor as a target enzyme in cancer therapy: Structural and functional insights from crystallography. [PDF]
Indian J PharmacolMagar VK +5 more
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Chronic Myeloid Leukemia Beyond BCR::ABL1 Inhibition: Resistance Mechanisms and Emerging Therapeutic Modalities. [PDF]
Pharmaceuticals (Basel)Mihaylova R.
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Cytochrome P450 inhibitors: friends or foes? [PDF]
Front ChemVyas SK, Ahmed MI, Dixit VA.
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Competition in drug binding and … the race to equilibrium
Fundamental & Clinical Pharmacology, 2022AbstractBinding kinetics has become a popular topic in pharmacology due to its potential contribution to the selectivity and duration of drug action. Yet, the overall kinetic aspects of complex binding mechanisms are still merely described in terms of elaborate algebraic equations.
Georges Vauquelin, Dominique Maes
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Competitive binding assays for riboflavin and riboflavin-binding protein
Analytical Biochemistry, 1982Abstract A competitive binding procedure that can be used to determine either riboflavin or riboflavin-binding protein has been developed. Riboflavin-binding protein from chicken egg white binds tightly to DEAE-cellulose while free riboflavin does not.
S E, Lotter +3 more
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Competitive hapten-antibody binding: Solution of the binding equation
Journal of Theoretical Biology, 1965Abstract The competitive binding equation which describes the reactions between two univalent homogeneous cross-reacting haptens and antibody heterogeneous with respect to equilibrium constants has been solved. The joint probability density function of equilibrium constants can be computed directly from binding measurements; no assumption about the ...
J, Wong, F, Aladjem
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ASSAY OF ALDOSTERONE BY COMPETITIVE PROTEIN BINDING
Acta Endocrinologica, 1970ABSTRACT We have applied a competitive protein binding technique to the assay of aldosterone, utilizing the aldosterone binding protein (ABP) in kidney as the specific receptor molecule. Intracellular ABP was obtained from the homogenization of adrenalectomized rat kidneys in 0.25 M sucrose.
R G, Robinson, D D, Fanestil
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Effect of transport and competition on ligand binding
Biophysical Chemistry, 1999We present a model to describe the physics of chemoreception in processes determined by competitive ligand binding. Our model describes the competition between various populations, such as ligands vs. blockers and receptors vs. decoys, in protein activation when diffusion is rate-determining.
C. A. CONDAT +3 more
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TESTOSTERONE ASSAYS BY COMPETITIVE PROTEIN BINDING
Acta Endocrinologica, 1970ABSTRACT A review of competitive protein binding methods for the determination of testosterone in plasma is given. The different steps discussed are: Choice of the binding protein, dilution of the protein solution, separation of the free from the bound fraction, purification of the extract and factors determining the blank.
A, Vermeulen, L, Verdonck
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