Results 111 to 120 of about 8,384,443 (422)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2 [PDF]

, 2015
Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors. Both proteins are subject to multiple levels of regulation of their DNA binding and transactivation properties.
Adams, Babayeva, Babayeva, Baillat, Baillat, Christopher D.O. Cooper, Cowley, Degnan, Desjardins, Emsley, Garvie, Goetz, Guen, Hagman, Hazel Aitkenhead, Hollenhorst, Jonsen, Joseph A Newman, Kabsch, Lamber, Lee, Lee, Lim, Opher Gileadi, Petersen, Pufall, Savitsky, Shaikhibrahim, Vagin, Venanzoni, Wang, Wang, Wasylyk, Wei   +33 more
core   +1 more source

PB2139: MONITORING OLIGOSECRETORY MULTIPLE MYELOMA USING MALDI-TOF MASS SPECTROMETRY

HemaSphere, 2023
Oscar Berlanga, Cristina Simion, Florence Njere, Amy Rollins, Natalia Panko, Sanchia Sarin, Deanna Willis, Sophie Caprioli, Jane Birtwistle, Syreeta Allen, Gemma Malin, Gabriella Lakos   +11 more
doaj   +1 more source

A naturally occurring carotenoid, lutein, reduces PDGF and H₂O₂ signaling and compromised migration in cultured vascular smooth muscle cells

Journal of Biomedical Science, 2012
Background Platelet-derived growth factor (PDGF) is a potent stimulator of growth and motility of vascular smooth muscle cells (VSMCs). Abnormalities of PDGF/PDGF receptor (PDGFR) are thought to contribute to vascular diseases and malignancy.
Lo Huey-Ming, Tsai Yih-Jeng, Du Wen-Yuan, Tsou Chih-Jen, Wu Wen-Bin   +4 more
doaj   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Comparative Structural Analysis of Human ACE2 Receptor with Spike Protein of SARS-CoV-2 Variants: Implications to Understand Infectivity of the Virus

Advances and Applications in Bioinformatics and Chemistry, 2022
Tirthankar Koley, Arunima Goswami, Manoj Kumar, Neelam Upadhyay, Gururao Hariprasad Department of Biophysics, All India Institute of Medical Sciences, New Delhi, 110029, IndiaCorrespondence: Gururao Hariprasad, Tel +91-11-26594240, Fax +91-11-26588663 ...
Koley T, Goswami A, Kumar M, Upadhyay N, Hariprasad G   +4 more
doaj  

MatInspector and beyond: promoter analysis based on transcription factor binding sites

Bioinform., 2005
MOTIVATION Promoter analysis is an essential step on the way to identify regulatory networks. A prerequisite for successful promoter analysis is the prediction of potential transcription factor binding sites (TFBS) with reasonable accuracy.
Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, Frisch M, Bayerlein M, Werner T, Kerstin Cartharius   +9 more
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Code-switching strategies in science lessons in Kenyan primary schools : an analysis of their contribution to the meaning making process [PDF]

, 2003
This study investigates how teachers in a rural Kenyan primary school use code-switching to help pupils to understand scientific concepts. The study takes place in a teaching and learning environment where English is the 'official' language of teaching ...
Binding, Matthew Paul
core  

Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. [PDF]

, 2018
Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous ...
Damotte, Vincent, Hollenbach, Jill, Misra, Maneesh   +2 more
core   +1 more source