Results 111 to 120 of about 6,725,434 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Integration of Realistic Episodic Memories Relies on Different Working Memory Processes: Evidence from Virtual Navigation

Frontiers in Psychology, 2018
Memory is one of the most important cognitive functions in a person’s life as it is essential for recalling personal memories and performing many everyday tasks.
Gaën Plancher, Gaën Plancher, Gaën Plancher, Valérie Gyselinck, Valérie Gyselinck, Pascale Piolino, Pascale Piolino, Pascale Piolino, Pascale Piolino   +8 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hardt's surprising sloppy readings : a flat binding account [PDF]

, 2009
The paper presents an additional argument for a specific account of semantic binding: the flat-binding analysis. The argument is based on observations concerning sloppy interpretations in verb phrase ellipsis when the binder is not the subject of the ...
Sauerland, Uli
core  

Baryon Binding Energy in Sakai-Sugimoto Model

, 2009
The binding energy of baryon has been studied in the dual $AdS_5\times S^5$ string theory with a black hole interior. In this picture baryon is constructed of a $D_5$ brane vertex wrapping on $S^5$ and $N_c$ fundamental strings connected to it.
C.P. Herzog, C.P. Herzog, E. Caceres, E. Caceres, E. Nakano, E. Witten, F.L. Lin, G. Curtis, G. Curtis, H. Liu, H. Liu, J. Erdmenger, J. Sadeghi, J. Sadeghi, J. Sadeghi, J. Sadeghi, J.D. Edelstein, J.H. Schwarz, J.L. Petersen, J.M. Maldacena, K. Peeters, M. Chernicoff, M. Chernicoff, M. R. Pahlavani, M. Rozali, N. Armesto, O. Bergmann, R. Morad, S. Heshmatian, S.D. Avramis, S.S. Gubser, T. Matsuo   +31 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Corrigendum: Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica

Frontiers in Neuroanatomy, 2020
Beata Tepper, Katarzyna Bartkowska, Malgorzata Okrasa, Sonia Ngati, Magdalena Braszak, Kris Turlejski, Ruzanna Djavadian   +6 more
doaj   +1 more source

A Concept-Value Network as a Brain Model

NeuroSci
This paper suggests a statistical framework for describing the relations between the physical and conceptual entities of a brain-like model. Features and concept instances are put into context, where the paper suggests that features may be the electrical
Kieran Greer
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source