Results 121 to 130 of about 3,573,689 (297)

Genome-Wide Binding Analysis of the Transcription Activator IDEAL PLANT ARCHITECTURE1 Reveals a Complex Network Regulating Rice Plant Architecture

, 2013
Zefu Lu, Hong Yu, Guosheng Xiong, Jing Wang, Yongqing Jiao, Guifu Liu, Yanhui Jing, Xiangbing Meng, Xingming Hu, Qian Qian, Xiangdong Fu, Yonghong Wang, Jiayang Li   +12 more
openalex   +1 more source

Substrate Binding Directs the Functional Hinge Bending Motion of Human 3-Phosphoglycerate Kinase [PDF]

, 2009
Erika Balog, Zoltan Palmai, Laurent Chaloin, Corinne Lionne, Judit Fidy, David Pérahia   +5 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Structural studies of the acetylcholine binding protein in complex with novel compounds [PDF]

, 2009
Line A. Thomsen, Thomas Bale, Marianne L. Jensen, Philip K. Ahring, J.S. Kastrup, Michael Gajhede   +5 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Influence of the RNA-Binding Protein HuR in pVHL-Regulated p53 Expression in Renal Carcinoma Cells

, 2003
Stefanie Galbán, Jennifer L. Martindale, Krystyna Mazan-Mamczarz, Isabel López de Silanes, Jinshui Fan, Wengong Wang, Jochen Decker, Myriam Gorospe   +7 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

eLife
The structural basis for the pharmacology of human G protein-coupled receptors (GPCRs), the most abundant membrane proteins and the target of about 35% of approved drugs, is still a matter of intense study.
Giuseppe Deganutti, Ludovico Pipito, Roxana Maria Rujan, Tal Weizmann, Peter Griffin, Antonella Ciancetta, Stefano Moro, Christopher Arthur Reynolds   +7 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Axonemal dynein light chain-1 locates at the microtubule-binding domain of the γ heavy chain

, 2015
Muneyoshi Ichikawa, Kei Saito, Haruaki Yanagisawa, Toshiki Yagi, Ritsu Kamiya, Shin Yamaguchi, Junichiro Yajima, Yasuharu Kushida, Kentaro Nakano, Osamu Numata, Yoko Y. Toyoshima   +10 more
openalex   +2 more sources