Utilidad del ensayo de cadenas livianas libres en suero en el manejo de gammapatías monoclonales
Revista Médica del Uruguay, 2014 El ensayo de cadenas livianas libres en suero cuantifica los niveles de κ y λ libres. Existen tres indicaciones principales para la medición de cadenas livianas libres en el manejo de pacientes con mieloma múltiple y enfermedades relacionadas.
María Florencia Delgado
doaj
Crowding-Regulated Binding of Divalent Biomolecules [PDF]
Phys. Rev. Lett. 130, 258401 (2023)Macromolecular crowding affects biophysical processes as diverse as diffusion, gene expression, cell growth, and senescence. Yet, there is no comprehensive understanding of how crowding affects reactions, particularly multivalent binding. Herein, we use scaled particle theory and develop a molecular simulation method to investigate the binding of ...
arxiv +1 more source
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Structural Analysis and Stochastic Modelling Suggest a Mechanism for Calmodulin Trapping by CaMKII [PDF]
, 2012 Activation of CaMKII by calmodulin and the subsequent maintenance of constitutive activity through autophosphorylation at threonine residue 286 (Thr286) are thought to play a major role in synaptic plasticity. One of the effects of autophosphorylation at
Le Novère, Nicolas +2 more
core +4 more sources
Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation.
Chemical Reviews, 2018 Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less specific electrostatic interactions, impart important properties to proteins.
Huan‐Xiang Zhou, Xiaodong Pang
semanticscholar +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Recovery of the m-function from spectral data for generalized Sturm–Liouville problems [PDF]
, 2004 The Sturm–Liouville problem −y″+qy=λy, y(0)cosα=y′(0)sinα, (y′/y)(1)=h(λ)/g(λ) is studied, where h and g are real polynomials. Generalized norming constants ρnk associated with eigenvalues Λn are defined and formulae are given for recovering the m ...
Binding, Paul A. +2 more
core +1 more source
Prediction of Flavin Mononucleotide (FMN) Binding Sites in Proteins Using the 3D Search Motif Method and Double-Centroid Reduced Representation of Protein 3D Structures [PDF]
arXiv, 2015 A pharmacophore consists of the parts of the structure of the ligand that are sufficient to express the biological and pharmacological effects of the ligand. It is usually a substructure of the entire structure of the ligand. Small organic molecules called ligands or metabolites in the cell form complexes with biomolecules (usually proteins) to serve ...
arxiv
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
PocketPicker: analysis of ligand binding-sites with shape descriptors [PDF]
, 2007 Background Identification and evaluation of surface binding-pockets and occluded cavities are initial steps in protein structure-based drug design.
Proschak, Ewgenij +2 more
core +3 more sources