Evaluation of the Method of Binding Tamoxifen to DNA Experimentally and Computationally [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021 Background and Aim: Tamoxifen is a group of drugs of selective estrogen receptor modulators, and is one of the drugs effective in the prevention and treatment of some cancers (such as breast cancer).
Fatemeh Sharafi Bajgan +2 more
doaj +1 more source
Bridging the Language Gap: An Empirical Study of Bindings for Open Source Machine Learning Libraries Across Software Package Ecosystems [PDF]
, 2022 Open source machine learning (ML) libraries enable developers to integrate advanced ML functionality into their own applications. However, popular ML libraries, such as TensorFlow, are not available natively in all programming languages and software package ecosystems.
arxiv +1 more source
Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations
BMC Immunology, 2019 Background We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after ...
Antony R. Parker +5 more
doaj +1 more source
Isogloss, 2022 Cross-linguistically, control complement clauses have been reported to allow overt pronominal subjects displaying the diagnostic properties of obligatory control (‘Overt PRO’; see Livitz (2011) and reference therein). Building on Gómez (2017), we extend
Kryzzya Gómez +2 more
doaj +1 more source
On infinite-dimensional differential equations [PDF]
, 1977 Differential equations ·x(t) = f(x(t), t) are exhibited in a general infinite-dimensional Banach space, failing each of the following in turn. (i) The set St of solution values x(t) from a given point x(0) is compact. (ii) St is connected.
Binding, Paul
core +1 more source
On a necessary aspect for the Riesz basis property for indefinite Sturm-Liouville problems [PDF]
, 2012 In 1996, H. Volkmer observed that the inequality \[(\int_{-1}^1\frac{1}{|r|}|f'|dx)^2 \le K^2 \int_{-1}^1|f|^2dx\int_{-1}^1\Big|\Big(\frac{1}{r}f'\Big)'\Big|^2dx \] is satisfied with some positive constant $K>0$ for a certain class of functions $f$ on $[-
Beals +23 more
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The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
Expert Opinion on Drug Discovery, 2015 Introduction: The molecular mechanics energies combined with the Poisson–Boltzmann or generalized Born and surface area continuum solvation (MM/PBSA and MM/GBSA) methods are popular approaches to estimate the free energy of the binding of small ligands ...
S. Genheden, U. Ryde
semanticscholar +1 more source
DeepDTA: deep drug–target binding affinity prediction [PDF]
Bioinform., 2018 Motivation The identification of novel drug‐target (DT) interactions is a substantial part of the drug discovery process. Most of the computational methods that have been proposed to predict DT interactions have focused on binary classification, where ...
Hakime Öztürk +2 more
semanticscholar +1 more source
Existence and Asymptotics of Eigenvalues of Indefinite Systems of Sturm–Liouville and Dirac Type [PDF]
, 2001 Existence and asymptotic behavior of eigenvalues of indefinite Sturm–Liouville and Dirac systems with integrable coefficients are investigated using Prüfer angle analysis.
Binding, P.A., Volkmer, H.
core +1 more source
Structural flexibility of intrinsically disordered proteins induces stepwise target recognition [PDF]
J. Chem. Phys. 139, 225103 (2013), 2013 An intrinsically disordered protein (IDP) lacks a stable three-dimensional structure, while it folds into a specific structure when it binds to a target molecule. In some IDP-target complexes, not all target binding surfaces are exposed on the outside, and intermediate states are observed in their binding processes.
arxiv +1 more source