Results 271 to 280 of about 1,037,789 (311)

Synthesis and binding affinities of fluoroalkylated raloxifenes

Bioorganic & Medicinal Chemistry, 2003
Three fluoroalkylated derivatives (1-3) of the selective estrogen receptor modulator (SERM), raloxifene, have been synthesized. The key step in the synthesis is the C-C bond formation of benzo[b]thiophene and a substituted phenyl group (ring C) using a Stille reaction.
Kyo Chul, Lee, Byung Seok, Moon, Jae Hak, Lee, Kyoo-Hyun, Chung, John A, Katzenellenbogen, Dae Yoon, Chi   +5 more
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Endotoxin-Binding Affinity of Sevelamer Hydrochloride

American Journal of Nephrology, 2008
<i>Background:</i> Sevelamer hydrochloride has been shown to attenuate circulating biomarkers of inflammation in patients with chronic kidney failure. We hypothesize that sevelamer hydrochloride binds bacterial endotoxin (ET) resulting in a decrease in ET levels and cytokine production.
Mary C, Perianayagam, Bertrand L, Jaber
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Multivalent Binding and Functional Affinity

1976
The evolutionary development of the architecture of the antibody molecule has provided in its contemporary form a distinctive structure superbly suited for multivalent interaction. In addition to multivalence, the general occurrence of multiple and identical antigenic determinants on the surfaces of infectious agents and neoplastic cells has led to the
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Ligand binding and affinity modulation of integrins

Biochemistry and Cell Biology, 1996
Integrins are cell adhesion receptors that mediate cell–cell and cell–extracellular matrix interactions. The extracellular domains of these receptors possess binding sites for a diverse range of protein ligands. Ligand binding is divalent cation dependent and involves well-defined motifs in the ligand. Integrins can dynamically regulate their affinity
E C, Tozer, P E, Hughes, J C, Loftus
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Affinity NMR:  Decoding DNA Binding

Journal of Combinatorial Chemistry, 1998
We have shown that affinity NMR can be used to edit a NMR spectrum so that ligands that have affinity to DNA can be observed in the presence of other nonbinding molecules. Diffusion encoded spectroscopy (DECODES) can be used to identify the binding ligands. We were able to identify Hoechst 33342 as binding to the Drew-Dickerson dodecamer d(CGCGAATTCGCG)
R C, Anderson, M, Lin, M J, Shapiro
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Calculation of Protein-Ligand Binding Affinities

Annual Review of Biophysics and Biomolecular Structure, 2007
Accurate methods of computing the affinity of a small molecule with a protein are needed to speed the discovery of new medications and biological probes. This paper reviews physics-based models of binding, beginning with a summary of the changes in potential energy, solvation energy, and configurational entropy that influence affinity, and a ...
Michael K, Gilson, Huan-Xiang, Zhou
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High affinity binding of the mastoparans by calmodulin

Biochemical and Biophysical Research Communications, 1983
Calmodulin exhibits high affinity, calcium-dependent binding of the mastoparans--a group of cytoactive tetradecapeptides. The dissociation constants for the peptide-calmodulin complexes determined in 0.20 N KCl, 1.0 mM CaCl2, pH 7.3 are approximately 0.3 nM for mastoparan, approximately 0.9 nM for mastoparan X, and approximately 3.5 nM for Polistes ...
D A, Malencik, S R, Anderson
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High-Affinity Binding of Melatonin to Hemoglobin

Biochemical and Molecular Medicine, 1995
Determination of melatonin by radioimmunoassay in plasma samples from hemolyzed blood often yields flawed values. We studied the possibility that hemoglobin can bind melatonin and the iodinated tracer 125I-melatonin. The specific binding of 125I-melatonin to purified bovine hemoglobin was found to be rapid, saturable, and reversible (Kd = 315 pM, Bmax =
E, Gilad, N, Zisapel
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Receptor-Based Prediction of Binding Affinities

Perspectives in Drug Discovery and Design, 1998
1 . pharmacological receptors: macromolecular complexes that can be activated by specific signal molecules (e.g. agonists), process followed by a specific biological response from the cell (organ) associated with these complexes; enzymes: proteins that catalyze specific biochemical reactions upon substrate (ligand) binding with (± high) specificity ...
Tudor I. Oprea, Garland R. Marshall
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α2-macroglobulin binding to cultured fibroblasts: Identification by affinity chromatography of high-affinity binding sites

Archives of Biochemistry and Biophysics, 1983
Binding sites having the properties of high-affinity receptors for activated alpha 2-macroglobulin (alpha 2M) have been purified over 100-fold from membranes of spontaneously transformed NIH-3T3 cells (J. A. Hanover, S.-y. Cheng, M. C. Willingham, and I. H. Pastan [1983] J. Biol. Chem. 258, 370-377).
J A, Hanover, J E, Rudick, M C, Willingham, I, Pastan   +3 more
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