Results 251 to 260 of about 1,526,997 (293)

Receptor-Based Prediction of Binding Affinities

Perspectives in Drug Discovery and Design, 1998
1 . pharmacological receptors: macromolecular complexes that can be activated by specific signal molecules (e.g. agonists), process followed by a specific biological response from the cell (organ) associated with these complexes; enzymes: proteins that catalyze specific biochemical reactions upon substrate (ligand) binding with (± high) specificity ...
Tudor I. Oprea, Garland R. Marshall
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Affinity purification of DNA-binding proteins

Journal of Biochemical and Biophysical Methods, 2001
The focus of this review is on DNA affinity chromatography, which is the most powerful tool for purification of DNA binding proteins. The use of nonspecific-, sequence specific- and single stranded-DNA affinity columns in purification of various DNA binding proteins is discussed.
H, Gadgil, S A, Oak, H W, Jarrett
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Calculation of Protein-Ligand Binding Affinities

Annual Review of Biophysics and Biomolecular Structure, 2007
Accurate methods of computing the affinity of a small molecule with a protein are needed to speed the discovery of new medications and biological probes. This paper reviews physics-based models of binding, beginning with a summary of the changes in potential energy, solvation energy, and configurational entropy that influence affinity, and a ...
Michael K, Gilson, Huan-Xiang, Zhou
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Assessing TRAIL's Binding Affinity

Science Signaling, 2000
The TRAIL protein is a member of the tumor necrosis factor family and can associate with two receptors (DR4 and DR5) and three decoy receptors [DcR1, DcR2, and osteoprotegerin (OPG)]. TRAIL-dependent apoptosis is dependent on DR4 or DR5 expression, yet the presence of decoy receptors does not necessarily block apoptosis. Prior observations
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Androgen receptor binding affinity: a QSAR evaluation

SAR and QSAR in Environmental Research, 2011
The multiparameter formulation of the COmmon REactivity PAttern (COREPA) approach has been used to describe the structural requirements for eliciting rat androgen receptor (AR) binding affinity, accounting for molecular flexibility. Chemical affinity for AR binding was related to the distances between nucleophilic sites and structural features ...
Todorov, M., Mombelli, Enrico, Ait-Aissa, Selim, Mekenyan, O.   +3 more
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Binding Affinities of Thyroxine-Binding Proteins in Turtle Plasma

General and Comparative Endocrinology, 1993
Binding affinities (Ka) for thyroxine (T4) by blood plasma and purified plasma proteins from two turtles, the slider (Trachemys scripta) and snapper (Chelydra serpentina), were compared with those of a human using equilibrium dialysis. The purified T4 binding protein (TBP) from T.
K A, Glennemeier, P, Licht
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Multivalent Binding and Functional Affinity

1976
The evolutionary development of the architecture of the antibody molecule has provided in its contemporary form a distinctive structure superbly suited for multivalent interaction. In addition to multivalence, the general occurrence of multiple and identical antigenic determinants on the surfaces of infectious agents and neoplastic cells has led to the
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Biomimetic Carbohydrate‐Binding Agents (CBAs): Binding Affinities and Biological Activities

ChemBioChem, 2019
AbstractMimicking nature in carbohydrate recognition—that is, by using noncovalent interactions exclusively—is a hot topic that has attracted the interest of many scientists in the last 30 years. Carbohydrates are challenging ligands of high biological relevance, playing central roles in several physiological and pathological processes.
Oscar Francesconi, Stefano Roelens
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Machine Learning to Predict Binding Affinity

2019
Recent progress in the development of scientific libraries with machine-learning techniques paved the way for the implementation of integrated computational tools to predict ligand-binding affinity. The prediction of binding affinity uses the atomic coordinates of protein-ligand complexes.
Gabriela, Bitencourt-Ferreira, Walter Filgueira, de Azevedo   +1 more
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Capillary affinity chromatography and affinity capillary electrophoresis of heparin binding proteins

ELECTROPHORESIS, 1998
AbstractA new approach for separation, capillary affinity chromatography, is introduced for studying the interaction of heparin with antithrombin III and secretory leukocyte proteinase inhibitor. Heparin is covalently immobilized on the surface of an etched capillary through a silane spacer.
X, Wu, R J, Linhardt
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