Calreticulin Binding Affinity for Glycosylated Laminin [PDF]
Journal of Biological Chemistry, 1996 Several lines of evidence indicate that calreticulin has lectin-like properties. As a molecular chaperone, calreticulin binds preferentially to nascent glycoproteins via their immature carbohydrates; this property closely resembles that seen for calnexin, a chaperone with extensive molecular identity to calreticulin. A cell surface form of calreticulin
J M, McDonnell +3 more
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Indonesian Journal of Chemistry, 2022 Currently, nanobody binding cortisol has been deposited in the database. Unfortunately, the affinity is still in micromolar order. Substituting hydrophobic residues in the binding pocket and utilizing CDR2 and CDR3 is the strategy to improve the affinity.
Umi Baroroh +4 more
doaj +1 more source
Beating the reaction limits of biosensor sensitivity with dynamic tracking of single binding events [PDF]
, 2018 The clinical need for ultrasensitive molecular analysis has motivated the development of several endpoint-assay technologies capable of single-molecule readout.
Sevenler, Derin +2 more
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PredPRBA: Prediction of Protein-RNA Binding Affinity Using Gradient Boosted Regression Trees
Frontiers in Genetics, 2019 Protein-RNA interactions play essential roles in many biological aspects. Quantifying the binding affinity of protein-RNA complexes is helpful to the understanding of protein-RNA recognition mechanisms and identification of strong binding partners.
Lei Deng, Lei Deng, Wenyi Yang, Hui Liu
doaj +1 more source
PSnpBind-ML: predicting the effect of binding site mutations on protein-ligand binding affinity
Journal of Cheminformatics, 2023 Protein mutations, especially those which occur in the binding site, play an important role in inter-individual drug response and may alter binding affinity and thus impact the drug’s efficacy and side effects.
Ammar Ammar +3 more
doaj +1 more source
Stereoelectronic effects on the binding of neutral Lewis bases to CdSe nanocrystals [PDF]
, 2018 Using P-31 nuclear magnetic resonance (NMR) spectroscopy, we monitor the competition between tri-nbutylphosphine (Bu3P) and various amine and phosphine ligands for the surface of chloride terminated CdSe nanocrystals.
Anderson, Nicholas C +4 more
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Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity
Bioorganic & Medicinal Chemistry Letters, 2000 Analogues of the benzazepine dopamine D1 receptor antagonist SCH-23390 incorporating the cyclo-pentadienyltricarbonyl-rhenium (CPTR) moiety were synthesized and evaluated pharmacologically. The CPTR derivatives retained affinity (0.3-2.9 nM) and D1 selectivity of the parent compound, supporting their use as neuropharmacological surrogates for 99mTc ...
G, Tamagnan +4 more
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Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]
, 2018 Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
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DeepDTA: deep drug–target binding affinity prediction [PDF]
Bioinformatics, 2018 Abstract Motivation The identification of novel drug–target (DT) interactions is a substantial part of the drug discovery process. Most of the computational methods that have been proposed to predict DT interactions have focused on binary classification, where the goal is to determine whether a DT ...
Öztürk, Hakime +2 more
openaire +3 more sources
DNA Binding in High Salt: Analysing the Salt Dependence of Replication Protein A3 from the Halophile Haloferax volcanii [PDF]
, 2012 Halophilic archaea maintain intracellular salt concentrations close to saturation to survive in high-salt environments and their cellular processes have adapted to function under these conditions.
Bunting, KA, Patoli, B, Winter, JA
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