Results 91 to 100 of about 2,894,166 (305)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

MEF-AlloSite: an accurate and robust Multimodel Ensemble Feature selection for the Allosteric Site identification model

Journal of Cheminformatics
A crucial mechanism for controlling the actions of proteins is allostery. Allosteric modulators have the potential to provide many benefits compared to orthosteric ligands, such as increased selectivity and saturability of their effect.
Sadettin Y. Ugurlu, David McDonald, Shan He   +2 more
doaj   +1 more source

Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na+/K+-ATPase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Cisplatin is the most widely used chemotherapeutic drug for the treatment of various types of cancer; however, its administration brings also numerous side effects. It was demonstrated that cisplatin can inhibit the Na+/K+-ATPase (NKA), which can explain
Jaroslava Šeflová, Petra Čechová, Tereza Štenclová, Marek Šebela, Martin Kubala   +4 more
doaj   +1 more source

Three-body bound states in a lattice

, 2009
We pursue three-body bound states in a one-dimensional tight-binding lattice described by the Bose-Hubbard model with strong on-site interaction. Apart from the simple strongly-bound "trimer" state corresponding to all three particles occupying the same ...
Petrosyan, David, Saenz, Alejandro, Valiente, Manuel   +2 more
core   +1 more source

Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy [PDF]

, 2011
Increasing insights into the involvement of endogenous lectins in disease processes fuel the interest to develop potent inhibitors. As a consequence, robust assay procedures are required. Due to their activity as adhesion/growth-regulatory effectors this
André, Sabine, Büchner, Claudia, Doose, Sören, Gabius, Hans-Joachim, Göhler, Antonia, Kaltner, Herbert   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Identification of the N-terminal Peptide Binding Site of Glucose-regulated Protein 94 [PDF]

, 2004
Because the stress protein GRP94 can augment presentation of peptides to T cells, it is important to define how it, as well as all other HSP90 family members, binds peptides.
Argon, Baker-LePain, Baker-LePain, Binder, Blachere, Blond-Elguindi, Breloer, Burkholder, Collins, Fontana, Gragerov, Imarai, Ishii, Kalkum, Liu, Meng, Nieland, Prendergast, Prodromou, Prodromou, Prodromou, Rai, Robert, Roe, Schagger, Scheibel, Scheibel, Schneidman-Duhovny, Schulte, Shields, Shields, Singh-Jasuja, Slavik, Smith, Soldano, Spee, Stebbins, Suto, Tamura, Vogen, Wassenberg, Wearsch, Wearsch, Zhang, Zhu   +44 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis

Beilstein Journal of Organic Chemistry, 2019
Thiamin diphosphate (ThDP)-dependent enzymes constitute a large class of enzymes that catalyze a diverse range of reactions. Many are involved in stereospecific carbon–carbon bond formation and, consequently, have found increasing interest and utility as
Ferran Planas, Michael J. McLeish, Fahmi Himo   +2 more
doaj   +1 more source

Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression [PDF]

, 2017
Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production.
Lengyel, Iván M., Morelli, Luis G.
core   +2 more sources