Results 141 to 150 of about 8,730,538 (402)

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Nature, 2020
R. Shi, Chao Shan, Xiaomin Duan, Zhihai Chen, Peipei Liu, Jinwen Song, Tao Song, Xiaoshan Bi, Chao Han, Lian-ao Wu, Ge Gao, Xue Hu, Yanan Zhang, Z. Tong, Weijing Huang, William J. Liu, Guizhen Wu, Bo Zhang, Lan Wang, J. Qi, H. Feng, Fu-Sheng Wang, Qihui Wang, G. Gao, Zhiming Yuan, Jinghua Yan   +25 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Escherichia coli phage ΦPNJ-9 adheres to mucus via a variant Hoc protein

Journal of Virology
Phages, as antagonists of bacteria, hold significant promise for combating drug-resistant bacterial infections. Their host specificity allows phages to target pathogenic bacteria without disrupting the gut microbiota, offering distinct advantages in the ...
Kailai Fu, Jiaqi Cui, Yao Li, Yuhan Zhang, Yang Wang, Jiaoling Wu, Xinru Chen, Feng Xue, Jianluan Ren, Jianjun Dai, Fang Tang   +10 more
doaj   +1 more source

ORegAnno: an open access database and curation system for literature-derived promoters, transcription factor binding sites and regulatory variation [PDF]

, 2006
Stephen B. Montgomery, Obi L. Griffith, Monica C. Sleumer, Casey Bergman, Misha Bilenky, Erin Pleasance, Yuliya Prychyna, X. Zhang, Steven J.M. Jones   +8 more
openalex   +1 more source

Stabilization of Guest Molecules inside Cation‐Lidded Cucurbiturils Reveals that Hydration of Receptor Sites Can Impede Binding

, 2023
Suhang He, Bing Huang, Bohuai Xiao, Shuai Chang, Marina Podalko, Werner M. Nau   +5 more
openalex   +1 more source

Voronoi binding site models [PDF]

Journal of Computational Chemistry, 1987
AbstractA frequently occurring problem in drug design and enzymology is that the binding constants for several compounds to the same site are known, but the geometry and energetic interactions of the site are not. This paper presents in detail a novel approach to the problem which accurately but compactly represents the allowed conformation space of ...
openaire   +3 more sources

Robust transcriptome-wide discovery of RNA binding protein binding sites with enhanced CLIP (eCLIP)

Nature Methods, 2016
As RNA-binding proteins (RBPs) play essential roles in cellular physiology by interacting with target RNA molecules, binding site identification by UV crosslinking and immunoprecipitation (CLIP) of ribonucleoprotein complexes is critical to understanding
Eric L. Van Nostrand, G. Pratt, Alexander A. Shishkin, C. Gelboin-Burkhart, Mark Y. Fang, B. Sundararaman, S. Blue, Thai B. Nguyen, Christine Surka, Keri Elkins, Rebecca Stanton, F. Rigo, M. Guttman, Gene W. Yeo   +13 more
semanticscholar   +1 more source

Halide binding by the purified halorhodopsin chromoprotein. II. New chloride-binding sites revealed by 35Cl NMR [PDF]

, 1984
Halorhodopsin is a light-driven chloride pump in the cell membrane of Halobacterium halobium. Recently, a polypeptide of apparent Mr = 20,000 has been purified that contains the halorhodopsin chromophore.
Chan, Sunney I., Falke, Joseph J., Lanyi, Janos K., Oesterhelt, Dieter, Steiner, Michael, Towner, Paul   +5 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Binding and Activating of Analgesic Crotalphine with Human TRPA1

Membranes
TRPA1 (Transient Receptor Potential Ankyrin 1), a cation channel predominantly expressed in sensory neurons, plays a critical role in detecting noxious stimuli and mediating pain signal transmission.
Mingmin Kang, Yanming Zhang, Xiufang Ding, Jianfu Xu, Xiaoyun Pang   +4 more
doaj   +1 more source