Results 151 to 160 of about 1,655,478 (266)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor. [PDF]

Nat Commun
Nagel J, Namasivayam V, Weinhausen S, Sierra-Marquez J, Baqi Y, Al Musawi HAM, Abdelrahman A, Vaaßen VJ, Schlegel JG, Taplick L, Torp J, Kubicek J, Maertens B, Geyer M, Claff T, Nicke A, Hagelueken G, Müller CE.   +17 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A binding site for the antibiotic GE81112 in the ribosomal mRNA channel. [PDF]

mBio
Schedlbauer A, Han X, van Bakel W, Kaminishi T, Ochoa-Lizarralde B, Iturrioz I, Çapuni R, Parry R, Zegarra R, Gil-Carton D, López-Alonso JP, Barragan Sanz K, Brandi L, Gualerzi CO, Fucini P, Connell SR.   +15 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Inhibition of VEGF₁₆₅-Induced Angiogenesis by Gold Nanoparticles through HQGQH as the Primary Binding Site. [PDF]

J Chem Inf Model
Wan J, Zhou Y, Zhu J, Lu Y, Lyu Y, Hao H, Lu Z, Duckworth CA, Liu Y, Zhou H, Yi Y, Chan KC, Huang X.   +12 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Neutralizing human monoclonal antibodies to poliovirus map to the receptor binding site. [PDF]

Nat Commun
Waddey BT, Charnesky AJ, Faust JE, DiNunno NM, Puligedda RD, Cho SH, Bator CM, Dong SD, Mahmood K, Chumakov KM, Dessain SK, Hafenstein SL.   +11 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Enhancing prebiotic production by engineering the levanbiose-binding site of <i>Erwinia tasmaniensis</i> levansucrase. [PDF]

RSC Adv
Charoenwongpaiboon T, Srichompoo Y, Chanket W, Benini S, Field RA, Lorthongpanich C, Pongsawasdi P, Deetanya P, Pichyangkura R, Wangpaiboon K.   +9 more
europepmc   +1 more source