Results 141 to 150 of about 1,655,478 (266)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Binding Site Vectors Enable Mapping of Cytochrome P450 Functional Landscapes. [PDF]

J Chem Inf Model
Kuvek T, Jandová Z, Schleifer KJ, Oostenbrink C.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Genetic diversity and population structure of Passiflora spp. using inter-primer binding site (iPBS) - retrotransposon markers. [PDF]

Mol Biol Rep
de Jesus ON, Costa EMR, Azevedo FQ, de Sousa VR, Gonçalves ZS, Lima LKS, Soares TL.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

N-Terminal Actin-Binding Site of Lmod2 Promotes Controlled Pointed End Elongation. [PDF]

Circ Res
Larrinaga TM, Smith GE, Tolkatchev D, Rast TJ, Bunch TA, Colson BA, Pappas CT, Kostyukova AS, Gregorio CC.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site. [PDF]

ACS Med Chem Lett
Reddy Guduru SK, Caldwell JP, Digianantonio KM, Prophet SM, Yang S, Gareiss P, Jones C, Harbin A, Driscoll B, Karim MF, Scott A, Patel A, Chapman AE, Crandall M, Miklossy G, Barczak NT, Stroppa AP, Corradi JP, Clark JJ, Chung MK, Reinhardt NR, Butcher WE, Wilson R, Stiff C, Fathizadeh A, Yuan L, Wang G, Dong H, Beno BR, Zimmermann K, Langley DR, Cacace AM, Békés M.   +32 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

CoBRA: compound binding site prediction using RNA language model. [PDF]

Brief Bioinform
Jang W, Shin WH.
europepmc   +1 more source