Results 171 to 180 of about 2,894,166 (305)

Functional dissection of the prototype foamy virus glycoprotein heparan sulfate binding site. [PDF]

Retrovirology
Büttrich M, Stanke-Scheffler N, Calcraft T, Rosenthal PB, Lindemann D.   +4 more
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

DGSite: A Well-Calibrated Deep Learning Framework for Protein-RNA Binding Site Prediction. [PDF]

ACS Omega
Zeng X, Zhao L, Wang H, Zhou D, Cheng Y, Shi S.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site. [PDF]

ACS Med Chem Lett
Reddy Guduru SK, Caldwell JP, Digianantonio KM, Prophet SM, Yang S, Gareiss P, Jones C, Harbin A, Driscoll B, Karim MF, Scott A, Patel A, Chapman AE, Crandall M, Miklossy G, Barczak NT, Stroppa AP, Corradi JP, Clark JJ, Chung MK, Reinhardt NR, Butcher WE, Wilson R, Stiff C, Fathizadeh A, Yuan L, Wang G, Dong H, Beno BR, Zimmermann K, Langley DR, Cacace AM, Békés M.   +32 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Binding Site Vectors Enable Mapping of Cytochrome P450 Functional Landscapes. [PDF]

J Chem Inf Model
Kuvek T, Jandová Z, Schleifer KJ, Oostenbrink C.   +3 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

CoBRA: compound binding site prediction using RNA language model. [PDF]

Brief Bioinform
Jang W, Shin WH.
europepmc   +1 more source