Results 171 to 180 of about 1,513,732 (317)

Benchmarking Zinc-Binding Site Predictors: A Comparative Analysis of Structure-Based Approaches. [PDF]

J Chem Inf Model
Ciofalo C, Laveglia V, Andreini C, Rosato A.   +3 more
europepmc   +1 more source

Mechanism of Adherence of Streptococcus mutans to Smooth Surfaces II. Nature of the Binding Site and the Adsorption of Dextran-Levan Synthetase Enzymes on the Cell-Wall Surface of the Streptococcus [PDF]

, 1974
Hidehiko Mukasa, Hutton D. Slade
openalex   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site. [PDF]

iScience
Frey AF, Schwan M, Weldert AC, Kadenbach V, Kopp J, Nidoieva Z, Zimmermann RA, Gleue L, Zimmer C, Jörg M, Friedland K, Helm M, Sinning I, Barthels F.   +13 more
europepmc   +1 more source

Location and characteristics of ribosomal protein binding sites in the 16S RNA of Escherichia coli [PDF]

, 1975
René Zimmermann, G A Mackie, Akira Muto, R.A. Garrett, Ernst Ungewickell, Chantal Ehresmann, Patrick Stiegler, J.P. Ebel, Peter Fellner   +8 more
openalex   +1 more source

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis. [PDF]

PLoS Pathog
Joseph A, Cheng X, Harding J, Al-Saleem J, Green P, Griffith M, Veis D, Rauch DA, Ratner L.   +8 more
europepmc   +1 more source

The synergistic binding of anions and Fe3+ by transferrin. Implications for the interlocking sites hypothesis.

, 1975
MR Schlabach, GW Bates
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression. [PDF]

Cell Rep
Shah K, Anastasakou E, Sejour L, Wang Y, Wert-Lamas L, Rauchet C, Studer S, Goller S, Distel RJ, Marasco W, Perera L, Vlachos IS, Novina CD.   +12 more
europepmc   +1 more source