Results 241 to 250 of about 2,877,073 (306)

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

MVRBind: multi-view learning for RNA-small molecule binding site prediction. [PDF]

Brief Bioinform
Chen S, Huang Z, Wang Y, Li Y, Tan YS, Deng L, Wu M.   +6 more
europepmc   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Correction to "Benchmarking Zinc-Binding Site Predictors: A Comparative Analysis of Structure-Based Approaches". [PDF]

J Chem Inf Model
Ciofalo C, Laveglia V, Andreini C, Rosato A.   +3 more
europepmc   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Targeting the RAGE-RIPK1 binding site attenuates diabetes-associated cognitive deficits. [PDF]

J Neuroinflammation
Gao L, Wu S, Hu B, Zhang Q, Wu Y, Li H, Qian Y, Huang C, Wen X, Li H, Cheng A, Song Y, Ying C, Zhou X.   +13 more
europepmc   +1 more source

Cryo-EM reveals an extrahelical allosteric binding site at the M₅ mAChR. [PDF]

Nat Commun
Burger WAC, Mobbs JI, Rana B, Wang J, Joshi K, Gentry PR, Yeasmin M, Venugopal H, Bender AM, Lindsley CW, Miao Y, Christopoulos A, Valant C, Thal DM.   +13 more
europepmc   +1 more source

Revealing the location and dynamics of a concealed binding site in the dopamine transporter. [PDF]

Nat Commun
Zhu R, Sandtner W, Stockner T, Heilinger A, Holy M, Kudlacek O, Wildling L, Saha K, Fröhlich AS, Bindl M, Tziortzouda P, Haider A, Gobl J, Suh SH, Khan JA, Bicher J, Kastner N, Ebner A, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.   +22 more
europepmc   +1 more source

A Single DNA Binding Site of DprA Dimer Is Required to Facilitate RecA Filament Nucleation. [PDF]

Int J Mol Sci
Bakhlanova I, Carrasco B, Alekseev A, Yakunina M, Morozova N, Khodorkovskii M, Petukhov M, Baitin D.   +7 more
europepmc   +1 more source

Engineering a Functional Histidine Brace Copper-Binding Site into a <i>De Novo</i>-Designed Protein Scaffold. [PDF]

JACS Au
La Gatta S, Leone L, Sgueglia G, Šimunić L, Liao YK, Vaněk O, Chino M, Nastri F, Chiesa M, Lombardi A.   +9 more
europepmc   +1 more source