Results 221 to 230 of about 1,655,478 (266)

Mitochondrial Binding Sites for Triiodothyronine

Endocrinology, 1978
Metabolic effects upon rat liver mitochondria have been observed by others within 2 min of injection of massive amounts of L-T4. Reported here is the subcellular distribution of 2--5 ng high specific activity [125I]L-T3 2 min after ip injection with and without a loading dose of 30 micrograms unlabeled T3.
R L, Greif, D, Sloane
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Rhizoxin binding to tubulin at the maytansine-binding site

Biochimica et Biophysica Acta (BBA) - General Subjects, 1987
The binding of rhizoxin, a potent inhibitor of mitosis and in vitro microtubule assembly, to porcine brain tubulin was studied. Tubulin possesses one binding site for rhizoxin per molecule with a dissociation constant (Kd) of 1.7.10(-7) M. Ansamitocin P-3, a homologue of maytansine, was a competitive inhibitor of rhizoxin binding, with an inhibition ...
M, Takahashi, S, Iwasaki, H, Kobayashi, S, Okuda, T, Murai, Y, Sato   +5 more
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Hormone binding site of corticosteroid binding globulin

Nature Structural & Molecular Biology, 1995
A new location for the hormone-binding site of corticosteroid binding globulin is propose based on experimental data, together with a sequence and structural alignment of the serpin ...
P, Edgar, P, Stein
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Substrate-binding sites in acetylcholinesterase

Trends in Pharmacological Sciences, 1991
Acetylcholinesterase is among the most efficient enzymes known. In order to provide an explanation for its catalytic and regulatory mechanisms, including the high turnover rate, the specific amino acid residues involved in substrate binding and hydrolysis need to be identified.
F, Hucho, J, Järv, C, Weise
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A citrate-binding site in calmodulin

Journal of Molecular Recognition, 1998
Calmodulin (CaM) is a major Ca2+ messenger which, upon Ca2+ activation, binds and activates a number of target enzymes involved in crucial cellular processes. The dependence on Ca2+ ion concentration suggests that CaM activation may be modulated by low-affinity Ca2+ chelators.
T, Neufeld, M, Eisenstein, K A, Muszkat, G, Fleminger   +3 more
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Database Searches for Binding Sites

Science, 2000
In their Report “Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons” (7 Apr., p. [136][1]), G. G. Loots and colleagues identify conserved noncoding sequences (CNSs) in orthologous regions of the interleukin (IL)-4/13/5 locus of ...
K, Murphy, K A, Frazer, G, Loots, E M, Rubin   +3 more
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Protein metal-binding sites

Current Opinion in Biotechnology, 1992
Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins.
J A, Tainer, V A, Roberts, E D, Getzoff
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The taxonomy of binding sites in proteins

Molecular and Cellular Biochemistry, 1978
Conservation of polypeptide fold and mode of ligand binding is frequently found within proteins of related function. Examples illustrating this phenomenon are taken from NAD linked enzymes, nucleotide binding proteins, polysaccharide binding proteins, heme binding proteins and enzymes with essential Fe--S complexes or zinc atoms.
M G, Rossmann, P, Argos
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Hydrophobic binding site in acetylcholinesterase

Journal of Medicinal Chemistry, 1975
The dissociation constants have been determined and compared for a series of reversible, noncovalent inhibitors of eel acetylcholinesterase that are structurally related to the very potent inhibitor, 1,2,3,4-tetrahydro-9-aminoacridine (THA).
George M. Steinberg, Morton L. Mednick, Jan Maddox, Robert Rice, Joyce Cramer   +4 more
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The Ribosome Binding Site Calculator

2011
The Ribosome Binding Site (RBS) Calculator is a design method for predicting and controlling translation initiation and protein expression in bacteria. The method can predict the rate of translation initiation for every start codon in an mRNA transcript.
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