Results 241 to 250 of about 2,894,166 (305)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Identification of the client-binding site on the Golgi membrane protein adaptor Vps74/yGOLPH3. [PDF]

iScience
Lesniak AM, Ye Z, Banfield DK.
europepmc   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

The structural effects of indel polymorphisms outside the binding site on RNA-protein interactions are shaped by selection. [PDF]

PLoS Comput Biol
Owusu-Ansah C, Shatoff E, Bundschuh R.
europepmc   +1 more source

An Orchestrated Interaction Network at the Binding Site of Human SERT Enables the Serotonin Occlusion and Import. [PDF]

Biochemistry
Zhao Z, Wen PC, Tajkhorshid E.
europepmc   +1 more source

The Introduction of a HuR-Binding Site in the 3' UTR and the CD47 Cytoplasmic Tail Enhances SARS-CoV-2 S-Protein Expression in Cells. [PDF]

Viruses
Pereverzev IM, Bakhno IA, Yakovleva KI, Dovydenko IS, Burkova EE.   +4 more
europepmc   +1 more source

Partial agonist antipsychotic drugs differentially interact with a secondary binding site at the dopamine D2 receptor. [PDF]

Int J Neuropsychopharmacol
Ågren R, Sahlholm K.
europepmc   +1 more source

Fine modulation of carbon flow in central carbon metabolism via ribosome-binding site modification in <i>Escherichia coli</i>. [PDF]

Metab Eng Commun
Sawada S, Imada T, Nagai H, Mundt P, Matsuda F, Shimizu H, Toya Y.   +6 more
europepmc   +1 more source

STK4 inhibits the E3 activity of HOIP by phosphorylating its allosteric ubiquitin-binding site. [PDF]

Cell Discov
Wang Y, Zhou X, Lin Z, Huang Y, Zhang Y, Liu H, Zhou Y, Liu J, Pan L.   +8 more
europepmc   +1 more source