Results 211 to 220 of about 1,655,478 (266)

Melatonin Binding Sites

Journal of Neurochemistry, 1988
Abstract: The distribution and characterization of specific melatonin binding sites were studied using 125I‐melatonin. Autoradiography revealed only three sites of specific melatonin binding in brain: the suprachiasmatic nuclei, the median eminence, and the small part of choroid plexus at the caudal end of the fourth ventricle.
openaire   +2 more sources

Anatomy of lipase binding sites: the scissile fatty acid binding site

Chemistry and Physics of Lipids, 1998
Shape and physico-chemical properties of the scissile fatty acid binding sites of six lipases and two serine esterases were analyzed and compared in order to understand the molecular basis of substrate specificity. All eight serine esterases and lipases have similar architecture and catalytic mechanism of ester hydrolysis, but different substrate ...
J, Pleiss, M, Fischer, R D, Schmid
openaire   +2 more sources

Interaction of the dibutylchloromethyltin chloride binding site with the carbodiimide binding site in mitochondria

Biochemical and Biophysical Research Communications, 1980
Abstract An examination of the effect of dibutylchloromethyltin/chloride on the carbodiimide binding proteolipid of mitrochondrial ATPase has revealed that in the presence of the alkyltin, (1) binding of dicyclohexycarbodiimide is decreased (2) the electron spin resonance spectrum of a nitroxide analogue of dicyclohexylcarbodiimide exhibits line ...
M D, Partis, E, Bertoli, D E, Griffiths, A, Azzi   +3 more
openaire   +2 more sources

What makes a binding site a binding site?

Current Opinion in Structural Biology, 1995
Organic probe molecules have recently been used to define hydrophobic binding sites on the surface of proteins. It appears that the presence of water on the surface of a protein plays a crucial role in the interaction between that protein and its binding site.
openaire   +2 more sources

Brain leukotriene C4 binding sites are S-alkylglutathione binding sites

European Journal of Pharmacology, 1989
Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-alkylglutathione binding sites ...
A M, Goffinet, A, Nguyen
openaire   +2 more sources

Ligand Binding With Continuous Modification of Binding Sites

Journal of Biomolecular Structure and Dynamics, 2004
Simultaneous formulation binding and structure modification of the binding site leads to binding process that can be analyzed within the framework of the non-linear theory of dynamic systems. Such an approach allows us to obtain several properties of the binding center: plurality of stationary (stable and unstable) states at binding, recognition of ...
V B, Arakelyan, S G, Haroutiunian, H H, Abgaryan, A V, Arakelyan, T S, Haroutunyan   +4 more
openaire   +2 more sources

Ethanol binding sites on proteins

Journal of Molecular Graphics and Modelling, 2017
This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are ...
Khrustalev, V. V., Khrustaleva, T. A., Lelevich, S. V.   +2 more
openaire   +3 more sources

On the receptor binding site of relaxins

International Journal of Peptide and Protein Research, 1988
Relaxin plays a critical role in viviparity and has recently been implicated as a hormone of oviparity as well. In most mammals relaxin causes the widening of the birth canal during parturition and suppresses uterine motility during pregnancy. Relaxins isolated from several species have shown a great deal of sequence variability, and speculations ...
E E, Büllesbach, C, Schwabe
openaire   +2 more sources

Metal-binding sites in proteins

Current Opinion in Biotechnology, 1991
A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design.
J A, Tainer, V A, Roberts, E D, Getzoff
openaire   +2 more sources

The binding site for C1q on IgG

Nature, 1988
In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and complement lysis. The first step in the complement cascade is the binding of C1q to the antibody.
A R, Duncan, G, Winter
openaire   +2 more sources