Results 251 to 260 of about 1,513,732 (317)

Optimized Cell‐Based Platform for Platelet‐Free Detection of Heparin‐Induced Thrombocytopenia Antibodies

Advanced Biology, EarlyView.
This study optimized a cell‐based ELISA for HIT antibody detection using PF4‐coated breast cancer cells (MDA‐MB‐231). Enhanced binding was observed at 50 mM NaCl and 4% paraformaldehyde fixation. Live MDA‐MB‐231 and HCT‐116 cells demontrated superior sensitivity and specificity, providing a promising platelet‐free alternative for clinical HIT diagnosis.
Li‐Yu Chen, Uwe Schirmer, Peter F. Zipfel, Doris Heinrich, Thi‐Huong Nguyen   +4 more
wiley   +1 more source

The Single Nucleotide Substitution T → A rs2072580 Damages the CREB1 Binding Site in the Bidirectional <i>SART3</i>/<i>ISCU</i> Promoter. [PDF]

Genes (Basel)
Degtyareva A, Antontseva E, Evseenko A, Orishchenko K, Merkulova T.   +4 more
europepmc   +1 more source

Probing the Histamine H₁ Receptor Binding Site to Explore Ligand Binding Kinetics. [PDF]

J Med Chem
Kuhne S, Bosma R, Kooistra AJ, Riemens R, Stroet MCM, Vischer HF, de Graaf C, Wijtmans M, Leurs R, de Esch IJP.   +9 more
europepmc   +1 more source

Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation. [PDF]

Proc Natl Acad Sci U S A
Shen CH, Komi Y, Nakagawa Y, Kamatari YO, Nomura T, Kimura H, Shida T, Burke J, Tamai S, Ishida Y, Tanaka M.   +10 more
europepmc   +1 more source

Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I. [PDF]

Chemistry
Horiuchi N, Omer R, Sugino F, Ogino N, Inoue Y, Aslamuzzaman K, Suzuki T, Sebti SM, Ohkanda J.   +8 more
europepmc   +1 more source

RTK_RAG: Leveraging Retrieval Augmented Generation with Multi-Window Convolutional Neural Networks for Superior ATP Binding Site Prediction in Receptor Tyrosine Kinases. [PDF]

J Chem Inf Model
Wei SS, Jhang WE, Liu YC, Chuang CC, Ou YY.   +4 more
europepmc   +1 more source

Evolution of a SHOOTMERISTEMLESS transcription factor binding site promotes fruit shape determination. [PDF]

Nat Plants
Hu ZC, Majda M, Sun HR, Zhang Y, Ding YN, Yuan Q, Su TB, Lü TF, Gao F, Xu GX, Smith RS, Østergaard L, Dong Y.   +12 more
europepmc   +1 more source

A binding site for the antibiotic GE81112 in the ribosomal mRNA channel

Schedlbauer A, Han X, van Bakel W, Kaminishi T, Ochoa-Lizarralde B, Iturrioz I, Çapuni R, Parry R, Zegarra R, Gil-Carton D, López-Alonso JP, Sanz KB, Brandi L, Gualerzi CO, Fucini P, Connell SR.   +15 more
europepmc   +1 more source

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Localization of the binding site on fibrin for the secondary binding site of thrombin

Biochemistry, 1988
Affinity chromatography of active site inhibited thrombin on immobilized fragments derived from the central (desAB-NDSK) and terminal (D1) globular domains of fibrinogen revealed that the site responsible for the binding of thrombin at its secondary fibrin binding site is located in the central domain.
Zsofia Vali, Harold A. Scheraga
openaire   +3 more sources