Results 261 to 270 of about 8,730,538 (402)

Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site. [PDF]

, 1993
Stephen Morris, Stephan Schröder, Uwe Plessmann, K. Weber, Ernst Ungewickell   +4 more
openalex   +1 more source

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

Nature Structural &Molecular Biology, 2013
R. Qi, Evans Boateng Sarbeng, Qun Liu, Katherine Le, Xinping Xu, Hongya Xu, Jiao Yang, J. Wong, C. Vorvis, W. Hendrickson, Lei Zhou, Qinglian Liu   +11 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

, 1994
Gregory M. Lipkind, Harry A. Fozzard
openalex   +2 more sources

Identification of Cell-binding Sites on the Laminin α5 N-terminal Domain by Site-directed Mutagenesis [PDF]

, 2001
Peter Kresten Nielsen, Yoshihiko Yamada
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

STK4 inhibits the E3 activity of HOIP by phosphorylating its allosteric ubiquitin-binding site. [PDF]

Cell Discov
Wang Y, Zhou X, Lin Z, Huang Y, Zhang Y, Liu H, Zhou Y, Liu J, Pan L.   +8 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

MVRBind: multi-view learning for RNA-small molecule binding site prediction. [PDF]

Brief Bioinform
Chen S, Huang Z, Wang Y, Li Y, Tan YS, Deng L, Wu M.   +6 more
europepmc   +1 more source

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor

Herman D. Lim, Damian Bartuzi, Alastair C. Keen, Caroline Rauffenbart, Jacqueline R. Glenn, Steven J. Charlton, Silvia Lovera, Zara A. Sands, Ali Ates, Martyn Wood, Meritxell Canals, Jonathan A. Javitch, Jens Carlsson, J. Robert Lane   +13 more
openalex   +1 more source