Results 331 to 340 of about 8,730,538 (402)

Colchicine Binding Site Tubulin Inhibitors Impair Vincristine-Resistant Neuroblastoma Cell Function. [PDF]

Molecules
Reed CN, Garrison KB, Thammathong J, Cinatl J, Michaelis M, Banerjee S, Weissmiller AM.   +6 more
europepmc   +1 more source

Correction to "Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD". [PDF]

Angew Chem Int Ed Engl
europepmc   +1 more source

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Binding Site Detection Remastered: Enabling Fast, Robust, and Reliable Binding Site Detection and Descriptor Calculation with DoGSite3

Journal of Chemical Information and Modeling, 2023
Binding site prediction on protein structures is a crucial step in early phase drug discovery whenever experimental or predicted structure models are involved. DoGSite belongs to the widely used tools for this task.
Joel Graef, C. Ehrt, M. Rarey
semanticscholar   +1 more source

Binding Site Diversity Promotes CO2 Electroreduction to Ethanol.

Journal of the American Chemical Society, 2019
The electrochemical reduction of CO2 has seen many record-setting advances in C2 productivity in recent years. However, the selectivity for ethanol, a globally significant commodity chemical, is still low compared to the selectivity for products such as ...
Yuguang C. Li, Ziyun Wang, T. Yuan, Dae-Hyun Nam, Mingchuan Luo, Joshua Wicks, Bin Chen, Jun Li, Fengwang Li, F. P. G. de Arquer, Ying Wang, C. Dinh, O. Voznyy, D. Sinton, E. Sargent   +14 more
semanticscholar   +1 more source

Localization of the binding site on fibrin for the secondary binding site of thrombin

Biochemistry, 1988
Affinity chromatography of active site inhibited thrombin on immobilized fragments derived from the central (desAB-NDSK) and terminal (D1) globular domains of fibrinogen revealed that the site responsible for the binding of thrombin at its secondary fibrin binding site is located in the central domain.
Z, Vali, H A, Scheraga
openaire   +2 more sources

Brain leukotriene C4 binding sites are S-alkylglutathione binding sites

European Journal of Pharmacology, 1989
Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-alkylglutathione binding sites ...
A M, Goffinet, A, Nguyen
openaire   +2 more sources

Antibody Binding Sites

1996
This chapter assesses advances in the understanding and manipulation of antibody binding sites and variable regions. The antigen binding region of an antibody reduced to a 25-kDa minimum comprises of a noncovalent heterodimer of V H and V L domains.
J S, Huston, M N, Margolies, E, Haber
openaire   +2 more sources

Cryptophycin 1 binds to tubulin at a site distinct from the colchicine binding site and at a site that may overlap the vinca binding site

Cancer Letters, 1996
Cryptophycin 1 is a new cytotoxic antimicrotubule agent with excellent antitumor activity. The methods of Sackett (Biochemistry, 34, 7010-7019, 1995), utilizing the selective and specific proteolysis of alpha- and beta-tubulin by trypsin and chymotrypsin, was used to identify the cryptophycin 1 binding site on tubulin.
S L, Mooberry, C R, Taoka, L, Busquets
openaire   +2 more sources

Benzodiazepine-Binding Site and Gaba-Binding Site

1983
There is a body of experimental evidence to suggest that the benzodiazepine-binding site, the GABA-binding site and the chloride ionophore are functionally correlated. To elucidate this issue, the interactions among these components in both membrane-bound state and soluble state are examined.
Li-ren Chang, Eric A. Barnard
openaire   +1 more source