Results 201 to 210 of about 1,507,897 (295)

LIGYSIS-web: a resource for the analysis of protein-ligand binding sites. [PDF]

Nucleic Acids Res
Utgés JS, MacGowan SA, Barton GJ.
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Amplified Recognition of Basic Anions Induced by Cooperative Interaction of Ureido-Binding Sites Preorganized by Azacalix[4]arene Skeleton. [PDF]

J Org Chem
Salvadori K, Matějka P, Lhoták P, Siri O.   +3 more
europepmc   +1 more source

Harpin of Pseudomonas syringae pv. phaseolicola Harbors a Protein Binding Site

, 2005
Chunmei Li, Minna Haapalainen, Justin Lee, Thorsten Nürnberger, Martin Romantschuk, Suvi Taira   +5 more
openalex   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

pH-Dependent Conformational Changes in Grb2 Monomer Reveal Different Binding Sites for Coumarin: An Insight for Small Molecule Drug Discovery. [PDF]

ACS Omega
Casteluci G, Dias RVR, Tedesco JA, Gouveia LE, de Oliveira ASGR, Caruso ÍP, de Melo FA.   +6 more
europepmc   +1 more source

Modular Insulators: Genome Wide Search for Composite CTCF/Thyroid Hormone Receptor Binding Sites

, 2010
Oliver Weth, Christine Weth, Marek Bartkuhn, Joerg Leers, Florian Uhle, Rainer Renkawitz   +5 more
openalex   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Advances in Methods for Accurate Prediction of RNA-Small Molecule Binding Sites: From Isolated to AI-Integrated Strategies. [PDF]

Pharmaceuticals (Basel)
Gao J, Zhuo C, Zeng C, Liu H, Zhao Y.
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source