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Metal-binding sites in proteins
Current Opinion in Biotechnology, 1991A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design.
J A, Tainer, V A, Roberts, E D, Getzoff
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The binding site for C1q on IgG
Nature, 1988In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and complement lysis. The first step in the complement cascade is the binding of C1q to the antibody.
A R, Duncan, G, Winter
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Mitochondrial Binding Sites for Triiodothyronine
Endocrinology, 1978Metabolic effects upon rat liver mitochondria have been observed by others within 2 min of injection of massive amounts of L-T4. Reported here is the subcellular distribution of 2--5 ng high specific activity [125I]L-T3 2 min after ip injection with and without a loading dose of 30 micrograms unlabeled T3.
R L, Greif, D, Sloane
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Ligand Binding With Continuous Modification of Binding Sites
Journal of Biomolecular Structure and Dynamics, 2004Simultaneous formulation binding and structure modification of the binding site leads to binding process that can be analyzed within the framework of the non-linear theory of dynamic systems. Such an approach allows us to obtain several properties of the binding center: plurality of stationary (stable and unstable) states at binding, recognition of ...
V B, Arakelyan +4 more
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Substrate-binding sites in acetylcholinesterase
Trends in Pharmacological Sciences, 1991Acetylcholinesterase is among the most efficient enzymes known. In order to provide an explanation for its catalytic and regulatory mechanisms, including the high turnover rate, the specific amino acid residues involved in substrate binding and hydrolysis need to be identified.
F, Hucho, J, Järv, C, Weise
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Rhizoxin binding to tubulin at the maytansine-binding site
Biochimica et Biophysica Acta (BBA) - General Subjects, 1987The binding of rhizoxin, a potent inhibitor of mitosis and in vitro microtubule assembly, to porcine brain tubulin was studied. Tubulin possesses one binding site for rhizoxin per molecule with a dissociation constant (Kd) of 1.7.10(-7) M. Ansamitocin P-3, a homologue of maytansine, was a competitive inhibitor of rhizoxin binding, with an inhibition ...
M, Takahashi +5 more
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Hormone binding site of corticosteroid binding globulin
Nature Structural & Molecular Biology, 1995A new location for the hormone-binding site of corticosteroid binding globulin is propose based on experimental data, together with a sequence and structural alignment of the serpin ...
P, Edgar, P, Stein
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A citrate-binding site in calmodulin
Journal of Molecular Recognition, 1998Calmodulin (CaM) is a major Ca2+ messenger which, upon Ca2+ activation, binds and activates a number of target enzymes involved in crucial cellular processes. The dependence on Ca2+ ion concentration suggests that CaM activation may be modulated by low-affinity Ca2+ chelators.
T, Neufeld +3 more
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Current Opinion in Biotechnology, 1992
Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins.
J A, Tainer, V A, Roberts, E D, Getzoff
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Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins.
J A, Tainer, V A, Roberts, E D, Getzoff
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Database Searches for Binding Sites
Science, 2000In their Report “Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons” (7 Apr., p. [136][1]), G. G. Loots and colleagues identify conserved noncoding sequences (CNSs) in orthologous regions of the interleukin (IL)-4/13/5 locus of ...
K, Murphy +3 more
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