Results 241 to 250 of about 1,682,340 (366)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

DCI-SiteDTA: drug-target affinity prediction based on binding sites detection and site-aware dual cross-interaction block. [PDF]

BMC Bioinformatics
Zhang J, Li X, Wei B, Zeng Y.
europepmc   +1 more source

Discovery ofNovel 4,5-Dihydropyrrolo[3,4‑c]pyrazol-6(2H)‑one-Based TubulinInhibitors Targeting Colchicine Binding Site with Potent Anti-OvarianCancer Activity

Quanwei Yu (2676865), Yujie Liu (188278), Zhijia Wang (1589848), Chengyong Wu (6650366), Ruofei Zhang (3589421), Lun Tan (4372222), Lele Zhang (388913), Cuiyu Guo (19359525), Lantu Gou (2279446), Weimin Li (131040), Yang He (307595), Yuxi Wang (450170)   +11 more
openalex   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

SwinSite: 3D Structure-Based Prediction of Protein-Ligand Binding Sites Using a Combined Vision Transformer and Convolution Model. [PDF]

J Chem Inf Model
Kim D, Lee J.
europepmc   +1 more source

Site-specific binding of urease to DNA origami rod in TEM.

Ian Murphy (7834241), Keren Bobilev (21156504), Daichi Hayakawa (6588020), Eden Ikonen (21156507), Thomas E. Videbæk (19013500), Shibani Dalal (21156510), Wylie W. Ahmed (21156513), Jennifer L. Ross (2283991), W. Benjamin Rogers (8462811)   +8 more
openalex   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Multiple overlapping binding sites determine transcription factor occupancy. [PDF]

Nature
Khetan S, Carroll BS, Bulyk ML.
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells. [PDF]

Nucleic Acids Res
Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L.   +7 more
europepmc   +1 more source