Results 261 to 270 of about 1,682,340 (366)

Site‐specific ORC binding, pre‐replication complex assembly and DNA synthesis at Schizosaccharomyces pombe replication origins

, 2002
Dong Kong, Melvin L. DePamphilis
openalex   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells. [PDF]

iScience
Faseela EE, Notani D, Sabarinathan R.
europepmc   +1 more source

Identification, Synthesis, and Characterization of New Glycogen Phosphorylase Inhibitors Binding to the Allosteric AMP Site

, 2004
Marit Kristiansen, Birgitte Andersen, Lars Iversen, Niels Westergaard   +3 more
openalex   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. [PDF]

J Biol Chem
Odell J, Nedza K, Lammerding J.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Water-Soluble Peptoids with Two Different Binding Sites for Strong ATP Chelation. [PDF]

Chemistry
Vorobyov N, Maayan G.
europepmc   +1 more source

Role of Hydrophilic Interaction in Binding of Hydroxylated 3-Deoxy C₁₉ Steroids to the Active Site of Aromatase

, 2001
Mitsuteru Numazawa, Keiko Yamada, Syoko Nitta, Chika Sasaki, Kanae Kidokoro   +4 more
openalex   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source