Results 111 to 120 of about 72,929 (276)

Evaluating the potential of high pressure high temperature and thermal processing on volatile compounds, nutritional and structural properties of orange and yellow carrots [PDF]

, 2015
The present study compares the impact of thermal and high pressure high temperature(HPHT) processing on volatile profile (via a non-targeted headspace fingerprinting) and structural and nutritional quality parameter (via targeted approaches) of orange ...
Delgado, Rosa, Elmore, J. Stephen, Grauwet, T., Hendrickx, M., Kebede, B. T., Lemmens, L., Manzoni, Filipa, Van Loey, A., Vervoort, L.   +8 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Case studies and evidence-based approaches to addressing urban soil lead contamination [PDF]

, 2017
Urban soils in many communities in the United States and internationally have been contaminated by lead (Pb) from past use of lead additives in gasoline, deterioration of exterior paint, emissions from Pb smelters and battery recycling and other ...
Ball, Andrew S., Brown, Sally, Filippelli, Gabriel M., Laidlaw, Mark A. S., Mielke, Howard W., Netherway, Pacian, Paz-Ferreiro, Jorge, Reichman, Suzie M., Truskewycz, Adam   +8 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Bioaccessibility of PBDEs present in indoor dust: a novel dialysis membrane method with a Tenax TA® absorption sink [PDF]

, 2018
Human uptake of flame retardants (FRs) such as polybrominated diphenyl ethers (PBDEs) via indoor dust ingestion is commonly considered as 100% bioaccessible, leading to potential risk overestimation.
Collins, Chris D., Kademoglou, Katerina, Williams, Adrian C.   +2 more
core   +1 more source

In vivo analysis of bovine colostrum whey-caseinate nanoparticles using rat model: Bio accessibility of immunoglobulins

Future Foods
The colostrum whey-sodium caseinate nanoparticles (NPs) were prepared with a diameter
Muhammad Umar, Uracha Rungsardthong Ruktanonchai, Davids Makararpong, Natchanon Rimsueb, Anil Kumar Anal   +4 more
doaj   +1 more source

Bioavailability and Bioactivity of Encapsulated Phenolics and Carotenoids Isolated from Red Pepper Waste

Molecules, 2019
In order to deactivate the health properties of bioactive compounds, they need to withstand the effects of food processing, their potential release from the food matrix, and remain bio-accessible in the gastrointestinal tract.
Jelena Vulić, Vanja Šeregelj, Ana Kalušević, Steva Lević, Viktor Nedović, Vesna Tumbas Šaponjac, Jasna Čanadanović-Brunet, Gordana Ćetković   +7 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Ultrasound-assisted extraction and encapsulation of betalain from prickly pear: Process optimization, in-vitro digestive stability, and development of functional gummies

Ultrasonics Sonochemistry
The study aimed to extract and encapsulate betalain pigment from prickly pear (Opuntia ficus-indica) using ultrasound-assisted extraction and eco-friendly glycerol.
Deepak Mehta, Kritika Kuksal, Kamlendra Yadav, Sudesh Kumar Yadav, Yuqin Zhang, Shivraj Hariram Nile   +5 more
doaj   +1 more source