Results 91 to 100 of about 1,191,896 (339)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Room temperature phosphorescent wood hydrogel

Nature Communications
Room temperature phosphorescent (RTP) hydrogels exhibit great potential but show poor mechanical performance (Tensile strengthen
Ruixia Liu, Hongda Guo, Shouxin Liu, Jian Li, Shujun Li, Tony D. James, Zhijun Chen   +6 more
doaj   +1 more source

A General Synthesis Method for Patterning PEDOT toward Wearable Electronics and Bioelectronics

Research
The conductive polymer poly-3,4-ethylenedioxythiophene (PEDOT), recognized for its superior electrical conductivity and biocompatibility, has become an attractive material for developing wearable technologies and bioelectronics.
Wanke Cheng, Zihao Zheng, Xiaona Li, Ying Zhu, Suqing Zeng, Dawei Zhao, Haipeng Yu   +6 more
doaj   +1 more source

A process for purifying xylosugars of pre-hydrolysis liquor from kraft-based dissolving pulp production process

Biotechnology for Biofuels, 2018
Background In the kraft-based dissolving pulp production process, pre-hydrolysis liquor (PHL) is produced, which contains hemicelluloses, lignin, furfural and acetic acid.
Jiachuan Chen, Jiran Dong, Guihua Yang, Ming He, Feng Xu, Pedram Fatehi   +5 more
doaj   +1 more source

Repeated pulse feeding induces functional stability in anaerobic digestion [PDF]

, 2013
Anaerobic digestion is an environmental key technology in the future bio-based economy. To achieve functional stability, a minimal microbial community diversity is required. This microbial community should also have a certain “elasticity”, i.e.
Aiyuk, Boon, Boon, Boon, Briones, Carballa, Conklin, De Vrieze, Dearman, Delbes, Fernandez, Greenberg, Haruta, Holm-Nielsen, Krakat, Lesteur, Marzorati, Mata-Alvarez, Muyzer, Peterson, Pycke, Read, Riviere, Verstraete, Verstraete, Wijekoon, Wittebolle, Wittebolle, Yu, Zamalloa   +29 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Preparation of and research on bioinspired graphene oxide/nanocellulose/polydopamine ternary artificial nacre

Materials & Design, 2019
Inspired by the hierarchical micro/nanoscale structure and interfacial interactions of natural nacre, a variety of bioinspired layered materials were designed and prepared.
Muzhi Li, Yuanyuan Miao, Xueyong Zhai, Yuxue Yin, Yuanting Zhang, Zhibin Jian, Xiuya Wang, Lipeng Sun, Zhenbo Liu   +8 more
doaj   +1 more source

Environmental analysis of innovative sustainable composites with potential use in aviation sector - A life cycle assessment review [PDF]

, 2017
The forecast of growing air transport in the upcoming decades faces the challenge of an increasing environmental impact. Aviation industry is working on promising technologies to mitigate this environmental impact. Lightweight design is a strong lever to
Bachmann, Jens, Bricout, Stéphanie, Hidalgo, Carme   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source