Results 171 to 180 of about 171,521 (301)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Targeting the Cardiovascular-Alzheimer's Disease Axis: The Promise of Marine Bioactive Peptides. [PDF]

Mar Drugs
Marasinghe CK, Youn K, Ho CT, Jun M.
europepmc   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Bioactive Peptides and Probiotic Bacteria: Modulators of Human Health. [PDF]

Foods
Wang Q, Zheng Y.
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Discovery of actinators, actin-derived bioactive peptides that modulate cytoskeleton and actin-related cellular activities. [PDF]

Sci Adv
Yi F, Guo J, Vo TT, Hetrick B, Haikerwal A, Zhou Z, Sealey L, He S, Han Y, Chilin L, Spear M, Yu D, Kim Y, Kashanchi F, Zhou T, Xu X, Lockhart C, Wu Y.   +17 more
europepmc   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

StarPepWeb: an integrative, graph-based resource for bioactive peptides. [PDF]

Bioinform Adv
López C, Cárdenas R, Aguilera-Mendoza L, Agüero-Chapin G, Martínez-Rios F, García-Jacas CR, Pérez-Pérez N, Marrero-Ponce Y.   +7 more
europepmc   +1 more source

Degradation and clearance of atrial natriuretic factors [PDF]

, 1990
Adnot, Almeida, Anand-Srivastava, Anand-Srivastava, Anderson, Ando, Arendt, Arendt, Ballermann, Ballermann, Bates, Bertrand, Bianchi, Bianchi, Cachofeiro, Cantin, Cantin, Chartier, Chinkers, Cody, Crozier, De Bold, De Lean, Drexler, Espiner, Fethiere, Fulcher, Gerbes, Gerbes, Gerbes, Gines, Gros, Gutkowska, Hasegawa, Henriksen, Hinko, Hollister, Inagami, Kenny, Koehn, Koepke, Kollenda, Koseki, Krieter, Kurosawa, Lafferty, Laffi, Lang, Lang, Laragh, Leitman, Lieorens, Luft, Maack, Mantyh, Marumo, Masuda, Matsas, Matsas, Matsas, Misono, Murthy, Nakao, Needleman, Northridge, Olins, Olins, Olins, Pandey, Porter, Predel, Raine, Richards, Riegger, Saito, Scarborough, Schafferhans, Schiebinger, Schutten, Schwartz, Seymour, Shima, Sonnenberg, Stephenson, Stewart, Sudhir, Sugiyama, Sybertz, Sybertz, Takayanagi, Tamburini, Tang, Thibault, Trapani, Trapani, Trippodo, Vierhapper, Vollmar, Vollmar, Vollmar, Webb, Woods, Yukimura   +102 more
core   +1 more source