Results 31 to 40 of about 388,078 (310)
Bioavailability of diphenylhydantoin [PDF]
Clinical Pharmacology & Therapeutics, 1974 A four‐way crossover study was performed in 8 adult volunteers using a Latin square design with 4 groups of 2 subiects arranged in order of increasing body weight. Single 100 mg doses of diphenylhydantoin (DPH) sodium were administered as an aqueous solution (treatment A), the innovator's capsule (treatment B), alld a commercially available generic ...
Albert, Kenneth S. +4 more
openaire +3 more sources
Towards bioavailability-based soil criteria : past, present and future perspectives [PDF]
, 2015 Bioavailability has been used as a key indicator in chemical risk assessment yet poorly quantified risk factor. Worldwide, the framework used to assess potentially contaminated sites is similar, and the decisions are based on threshold contaminant ...
Harmsen, Joop +25 more
core +1 more source
Journal of Advanced Research, 2016 Timolol maleate (TiM), a nonselective β-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from extensive first pass effect, resulting in a reduction of oral bioavailability (F%) to 50% and a short ...
Nadia M. Morsi +2 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2009 An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core
Effects of paper sludge addition on the bioavailability and distribution of Pb in contaminated soil [PDF]
, 2015 Heavy metal contamination of soil poses risks and hazards to environment and human being. Many amendments were used to remediate the contaminated soil. In this report, paper sludge was used to reduce the bioavailability of Pb in soil, and the remediation
Li, Zhen-Shan +3 more
core +1 more source
The Role of Thiol-Cysteine Sensitivity in Modulating the Bioavailability and Efficacy of Drug Candidates [PDF]
, 2023 Thiols are essential biomolecules involved in many biological processes, including redox regulation and signal transduction. Thiols are ubiquitous in biological systems and can be reversibly modified by electrophilic compounds through a mechanism known ...
Kendis, Parks +2 more
core +1 more source
Frontiers in PharmacologyPhenytoin is a first-line antiepileptic drug with narrow therapeutic range and follows non-linear pharmacokinetics. Pharmacokinetics of phenytoin have been studied in plasma matrix before, however, there were several disadvantages.
Yahdiana Harahap +3 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source