Results 51 to 60 of about 385,548 (309)

Rapid RP-HPLC-UV determination of molnupiravir, nirmatrelvir, and remdesivir alone, in pharmaceutical mixture and plasma

Discover Chemistry
Molnupiravir, nirmatrelvir, and remdesivir are antiviral drugs used in the latest COVID-19 treatment protocols. The proposed method describes a simple, sensitive, and accurate reversed-phase high-performance liquid chromatography (RP-HPLC-UV) for ...
Osama A. Abd-Elmegid, Mounir Zaky, Khaled Elgendy   +2 more
doaj   +1 more source

Evaluating the potential health risk of organochlorine pesticides in selected protein foods from Abeokuta southwestern Nigeria

Environmental Pollutants & Bioavailability, 2020
This study evaluated the potential health risk of OCPs in selected protein foods. A total of 66 food samples were collected from selected areas in Abeokuta, southwestern Nigeria. Food samples were analyzed for OCPs using the standard method.
Adewale Matthew Taiwo, Oluseye Philip Talabi, Abdulahi Akingbolahan Akintola, Ezekiel Tosin Babatunde, Moarufat Olajumoke Olanrewaju, Boluwatife Helen Adegbaju, Samson Lekan Odebo, Aishat Ajoke Bello, Oluwatosin Fatimah Matti, Adeniran Anthony Adesanya, Sakinat Mojisola Ahmad   +10 more
doaj   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Pharmacokinetics of single‐dose rivaroxaban under fed state in obese vs. non‐obese subjects: An open‐label controlled clinical trial (RIVOBESE‐PK)

Clinical and Translational Science
The evidence of rivaroxaban's pharmacokinetics in obese compared with non‐obese populations remains inconclusive. We aimed to compare the pharmacokinetic profile of rivaroxaban between obese and non‐obese populations under fed state. Participants who met
Majdoleen Alalawneh, Ahmed Awaisu, Ibtihal Abdallah, Hazem Elewa, Mohammed Danjuma, Kamal M. Matar, Akram M. ElKashlan, Yasser Elshayep, Fathy Ibrahim, Ousama Rachid   +9 more
doaj   +1 more source

Stream order and connectivity affect phosphorus distribution in plain river network

Environmental Pollutants & Bioavailability, 2020
The order and connectivity of streams influence phosphorus distribution extensively. In this work, the space-and-time variabilities of total phosphorus (TP), particulate phosphorus (PP), total dissolved phosphorus (TDP), dissolved reactive phosphorus ...
Huihua Lyu, Feng Zhou, Na Li
doaj   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Enhanced biodegradation of m-dichlorobenzene by Brevibacillus agri under the coexistence system of Zn(II) and Se(IV)

Environmental Pollutants & Bioavailability, 2020
Appropriate concentration of biological growth additives can improve the treatment effect of organic waste gas by microorganisms. In this work, the growth capability of Brevibacillus agri and the biodegradation efficiency of m-dichlorobenzene were ...
Bairen Yang, Yue Li, Qingqing Shang, Menglei Wu, Qi Zhou, Qi Xu, Cheng Ding   +6 more
doaj   +1 more source

Towards bioavailability-based soil criteria : past, present and future perspectives

, 2015
Bioavailability has been used as a key indicator in chemical risk assessment yet poorly quantified risk factor. Worldwide, the framework used to assess potentially contaminated sites is similar, and the decisions are based on threshold contaminant ...
Harmsen, Joop, Semple, K.T., McGrath, Steve, Harmsen, J., McConnell, S., Pruszinski, Andrew, McGrath, S., Dries, V., Naidu, R., Pruszinski, A., Palanisami, T., McGrath, S. P., Nathanail, Paul, Channey, Rufus, McConnell, Stuart, Dries, Victor, Channey, R., Johnston, Niall, MacMillan, J., Palanisami, Thavamani, Nathanail, P., Macmillan, Janet, Johnston, N., Semple, K. T., Semple, Kirk T., Naidu, Ravi   +25 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Biodegradation of o-dichlorobenzene by Bacillus cereus DL-1：kinetics, degradation pathway, biodegradability and performance in biotrickling filter

Environmental Pollutants & Bioavailability, 2020
o -Dichlorobenzene could be mineralized as the sole carbon and energy source by Bacillus cereus DL-1. In this work, Haldane–Andrews and pseudo-first-order models were used to simulate the growth and degradation abilities of the strain.
Bairen Yang, Yue Li, Qingqing Shang, Cheng Ding, Qi Xu   +4 more
doaj   +1 more source