Results 61 to 70 of about 385,548 (309)

Formulation and processing technologies for enhanced oral bioavailability of poorly water soluble compounds [PDF]

open access: yes, 2009
textDevelopments in high throughput screening and combinatorial chemistry have contributed to the unprecedented success of the pharmaceutical industry over the last twenty years, leading to a multitude of blockbuster compounds that revolutionized ...
DiNunzio, James Carlo
core  

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

open access: yesAdvanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni   +13 more
wiley   +1 more source

Spatial and temporal trends in total organic carbon (TOC), black carbon (BC), and total nitrogen (TN) and their relationships under different planting patterns in a restored coastal mangrove wetland: case study in Fujian, China

open access: yesChemical Speciation & Bioavailability, 2018
This study aims to determine the sediment changes and the trends in TOC, BC and TN before and after restoration of the mangrove wetland in the Jinjiang Estuary and to determine the effect of the wetland restoration process on the biogeochemical cycle of ...
Peiyong Guo   +4 more
doaj   +1 more source

Preliminary study of the distribution and risk assessment of mercury in different surficial sediments along the coastal area of the province Thai Binh in Vietnam

open access: yesEnvironmental Pollutants & Bioavailability, 2020
Surficial sediment samples along the coastal area of the province Thai Binh in Vietnam have been collected and analysed by modified Tessier method for the mercury content.
Thi Lim Duong   +10 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

open access: yesAdvanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu   +4 more
wiley   +1 more source

Spatial distribution of total halogenated organic compounds (TX), adsorbable organic halogens (AOX), and heavy metals in wetland soil irrigated with pulp and paper wastewater

open access: yesChemical Speciation & Bioavailability, 2017
Long-term irrigation using wastewater from paper industry may cause seriously problems to the receiving soil. This work surveyed and monitored the soil quality of a wastewater irrigation wetland system in Yancheng City, Jiangsu Province in China in 2014 ...
Liqiang Cui   +8 more
doaj   +1 more source

Effects of paper sludge addition on the bioavailability and distribution of Pb in contaminated soil

open access: yes, 2015
Heavy metal contamination of soil poses risks and hazards to environment and human being. Many amendments were used to remediate the contaminated soil. In this report, paper sludge was used to reduce the bioavailability of Pb in soil, and the remediation
Li, Zhen-Shan   +3 more
core   +1 more source

The Role of Thiol-Cysteine Sensitivity in Modulating the Bioavailability and Efficacy of Drug Candidates

open access: yes, 2023
Thiols are essential biomolecules involved in many biological processes, including redox regulation and signal transduction. Thiols are ubiquitous in biological systems and can be reversibly modified by electrophilic compounds through a mechanism known ...
Kendis, Parks   +2 more
core   +1 more source

Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release

open access: yesAdvanced Healthcare Materials, EarlyView.
A fundamental mechanism for the simultaneous control of multiple magnetic valves is reported in a miniature soft robotic patch for intravesical drug delivery, enabling fully wireless and programmable liquid release. Integrated with a bioadhesive interface and induction‐coupling‐based liquid volume sensing, the soft robotic patch is promising to enable ...
Boyang Xiao   +5 more
wiley   +1 more source

Changes in phosphorus fractions caused by increased microbial activity in forest soil in a short-term incubation study

open access: yesChemical Speciation & Bioavailability, 2018
The effects of adding larch (Larix kaempferi) leaf litter and nitrogen (N) on microbial activity and phosphorus (P) fractions in forest soil were examined in a short-term (28-d) laboratory incubation study.
Takashi Kunito   +4 more
doaj   +1 more source

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