Results 121 to 130 of about 54,975 (247)

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

Crystal Engineering as an Efficient Medicinal Chemistry Tool for Animal PK Bioavailability Enhancement in Early Pre-Clinical Research. [PDF]

Pharmaceuticals (Basel)
Becker A, von Essen C, Burgdorf L, Lecomte M, Bischof D.   +4 more
europepmc   +1 more source

Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection. [PDF]

Molecules, 2022
Li J, Chen G, Meng Z, Wu Z, Gan H, Zhu X, Han P, Liu T, Wang F, Gu R, Dou G.   +10 more
europepmc   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Diosgenin-mediated NF-κB and MAPK pathway modulation for osteoarthritis treatment: molecular mechanisms, bioavailability enhancement, and therapeutic applications. [PDF]

Inflammopharmacology
Adarkar R, Viswambharan VL, Dessai A, Lobo R, Tippavajhala VK, Pai V, Subraya CK, Aswatha Ram HN.   +7 more
europepmc   +1 more source

Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan. [PDF]

Pharmaceuticals (Basel), 2021
Giri BR, Kwon J, Vo AQ, Bhagurkar AM, Bandari S, Kim DW.   +5 more
europepmc   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Bioavailability Enhancement of Curcumin by PEG-Based Gastroretentive System: Development and In Vitro Evaluation. [PDF]

Pharmaceutics
Csendes O, Vasvári G, Haimhoffer Á, Horváth L, Béresová M, Bényei A, Bácskay I, Fehér P, Ujhelyi Z, Nemes D.   +9 more
europepmc   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Advancements in curcuminoid formulations: An update on bioavailability enhancement strategies curcuminoid bioavailability and formulations. [PDF]

Open Life Sci
Darmonkow A, Rowe ZEM, Harding SV.
europepmc   +1 more source