Results 131 to 140 of about 991,955 (291)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery. [PDF]

Pharmaceutics, 2023
Lal DK, Kumar B, Kumar B, Saeedan AS, Ansari MN.   +4 more
europepmc   +1 more source

Self-emulsifying drug delivery systems and their utilization for bioavailability enhancement

, 2019
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Consultant: PharmDr. Barbora Vraníková, Ph.D. Student: Zuzana Semričová Title of Thesis: Self-emulsifying drug delivery systems and their utilization for ...
Semričová, Zuzana
core  

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Nanoemulsions as novel oral carriers of stiripentol: insights into the protective effect and absorption enhancement

International Journal of Nanomedicine, 2015
Rong Lu,1 Shan Liu,1 Qilin Wang,1 Xia Li1,2 1School of Ocean, Shandong University, Weihai, 2School of Pharmaceutical Sciences, Shandong University, Jinan, People’s Republic of China Abstract: Oral administration remains a significant challenge
Lu R, Liu S, Wang Q, Li X
doaj  

Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin. [PDF]

Molecules, 2022
Liu Q, Sun H, Li X, Sheng H, Zhu L.
europepmc   +1 more source

Riparian and stream enhancement project evaluation

, 2002
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF title page (viewed on Oct. 19, 2006)"8-30-02."

core  

Phospholipid-based solid drug formulations for oral bioavailability enhancement:a meta-analysis

, 2015
Low bioavailability nowadays often represents a challenge in oral dosage form development. Solid formulations composed of drug and phospholipid (PL), which, upon contact with water, eventually form multilamellar liposomes (i.e.
Bauer-Brandl, Annette ; id_orcid, Fong, Sophia Yui Kau, Brandl, Martin; id_orcid   +2 more
core   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

Enhancing Osteoporosis Treatment through Targeted Nanoparticle Delivery of Risedronate: In Vivo Evaluation and Bioavailability Enhancement. [PDF]

Pharmaceutics, 2023
Saifi Z, Shafi S, Ralli T, Jain S, Vohora D, Mir SR, Alhalmi A, Noman OM, Alahdab A, Amin S.   +9 more
europepmc   +1 more source