Results 51 to 60 of about 991,955 (291)

Nanotechnology-enabled delivery of phytoconstituents: Recent developments, applications, and regulatory considerations

Asian Pacific Journal of Tropical Biomedicine
Nanotechnology has revolutionized drug delivery, particularly through nanoformulations of phytoconstituents, enhancing their therapeutic potential.
Mohd. Danish Ansari, Haya Majid, Syed Mahmood, Zarif Mohamed Sofian, Asif Husain, Yasmin Sultana, Faiyaz Shakeel   +6 more
doaj   +1 more source

Nanocrytals-Mediated Oral Drug Delivery: Enhanced Bioavailability of Amiodarone

Pharmaceutics, 2022
The aim of this study was to improve the saturation solubility, dissolution profile and oral bioavailability of amiodarone hydrochloride (AMH), a highly lipophilic drug.
Anum Munir Awan, Arshad Farid, Shefaat Ullah Shah, Dildar Khan, Fiza Ur Rehman, Muhammad Junaid Dar, Tayyaba Iftikhar, Shakira Ghazanfar, Charis M. Galanakis, Abdulhakeem S. Alamri, Syed Mohammed Basheeruddin Asdaq, Kifayat Ullah Shah   +11 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

The Development of Lipid-Based Sorafenib Granules to Enhance the Oral Absorption of Sorafenib

Pharmaceutics, 2023
Sorafenib (SFN) is an anticancer multi-kinase inhibitor with great therapeutic potential. However, SFN has low aqueous solubility, which limits its oral absorption.
Jaylen C. Mans, Xiaowei Dong
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Black cumin (Nigella sativa) oleosome as a natural delivery system for curcumin: characterization, preparation, and in vitro digestive behavior

Frontiers in Nutrition
Oleosomes, also known as oil bodies (OBs), are naturally occurring colloidal particles present in edible plant seeds and nuts and possess unique functional properties.
Negin Hosseini, Zahra Emam-Djomeh, Gholamreza Askari, Ali Hashemi Nejad, Haniye Takbirgou, Raimar Lobenberg, Neal M. Davies, Michael J. Serpe, Maryam Salami, Maryam Salami, Maryam Salami   +10 more
doaj   +1 more source

Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs

Pharmaceutics, 2021
Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of the weakly basic drug at elevated ...
Deanna M. Mudie, Aaron M. Stewart, Jesus A. Rosales, Nishant Biswas, Molly S. Adam, Adam Smith, Christopher D. Craig, Michael M. Morgen, David T. Vodak   +8 more
doaj   +1 more source

Buccal films of prednisolone with enhanced bioavailability [PDF]

Drug Delivery, 2014
The conventional formulation of prednisolone is considered to be low in efficacy, primarily on account of their failure in providing and maintaining effective therapeutic drug levels. This study aims to focus on development of a mucoadhesive buccal delivery system with a twofold objective of offering a rapid as well as a prolonged delivery of ...
Rachna, Kumria, Anroop B, Nair, Garima, Goomber, Sumeet, Gupta   +3 more
openaire   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Etoposide Amorphous Nanopowder for Improved Oral Bioavailability: Formulation Development, Optimization, in vitro and in vivo Evaluation

International Journal of Nanomedicine, 2020
Yue Wang, Shuhang Wang, Yingju Xu, Ping Wang, Sukai Li, Lu Liu, Mengyan Liu, Xiangqun Jin School of Pharmacy, Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Xiangqun Jin Tel +86-138-4409-0377Fax +86-431-8561-9662Email jinxq ...
Wang Y, Wang S, Xu Y, Wang P, Li S, Liu L, Liu M, Jin X   +7 more
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