Results 31 to 40 of about 991,955 (291)

Quality by Design Based Formulation of Xanthohumol Loaded Solid Lipid Nanoparticles with Improved Bioavailability and Anticancer Effect against PC-3 Cells

Pharmaceutics, 2022
Many natural products with greater therapeutic efficacy are limited to target several chronic diseases such as cancer, diabetes, and neurodegenerative diseases. Among the natural products from hops, i.e., Xanthohumol (XH), is a prenylated chalcone.
Vancha Harish, Devesh Tewari, Sharfuddin Mohd, Pilli Govindaiah, Malakapogu Ravindra Babu, Rajesh Kumar, Monica Gulati, Kuppusamy Gowthamarajan, SubbaRao V. Madhunapantula, Dinesh Kumar Chellappan, Gaurav Gupta, Kamal Dua, Siva Dallavalasa, Sachin Kumar Singh   +13 more
doaj   +1 more source

Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement. [PDF]

Bioengineering (Basel), 2018
The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs).
Kevadiya BD, Barvaliya M, Zhang L, Anovadiya A, Brahmbhatt H, Paul P, Tripathi C.   +6 more
europepmc   +2 more sources

Innovative Strategies to Enhance the Bioavailability of Cannabidiol: Nanotechnology and Advanced Delivery Systems

Pharmaceuticals
Cannabidiol (CBD), a phytocannabinoid with therapeutic potential for neurological and other conditions, faces significant challenges in bioavailability due to its low water solubility, high lipophilicity, and extensive first-pass metabolism.
Magdalena Paczkowska-Walendowska, Piotr Trzaskoma, Aleksandra Dziopa, Arash Moeini, Michał Soczawa, Zbigniew Krasiński, Judyta Cielecka-Piontek   +6 more
doaj   +1 more source

The Effect of Chemical Modifications of Chitosan on Intestinal Permeability and Oral Bioavailability of Carbamoylphosphonate JS403

, 2020
Art. 392, 8 S.JS403, Carbamoylphosphonate molecule, is a promising drug candidate with anti-metastatic activity. The polarityand water solubility of JS403 evolve from the phosphonate moiety that is ionized at physiologic pH.
Reich, Reuven, Bitton-Dotan, Reut, Tsuriel, Marina, Storsberg, Joachim, Hoffman, Amnon, Tulichala, RN Prasad, Bohrisch, Jörg, Breuer, Eli, Schmidt, Christian   +8 more
core   +1 more source

LIQUISOLID TECHNIQUE FOR DISSOLUTION AND BIOAVAILABILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS [PDF]

, 2017
Liquisolid formulations have attracted substantial interest as an efficient means of improving the dissolution and ultimately bioavailability. The technique is based upon the admixture of drug loaded solutions with appropriate carrier, coating materials ...
null null, Magdum, Shrikant S., Shrikant S. Magdum   +2 more
core   +1 more source

Novel phytosomal drug delivery systems in cancer therapy: advances, mechanisms, and translational potential

Journal of Applied Pharmaceutical Research
Background: Phytochemicals are medicinal plants with strong anticancer properties that alter various molecular pathways involved in tumor initiation, progression, and metastasis.
Sujatha Damera, Mounika Kuchukuntla, Mani Sharma, Ram Mohan Manda, Ananda Kumar Chettupalli, Rajendra Kumar Jadi   +5 more
doaj   +1 more source

Bioavailability enhancers of herbal origin: An overview [PDF]

Asian Pacific Journal of Tropical Biomedicine, 2013
Recently, the use of herbal medicines has been increased all over the world due to their therapeutic effects and fewer adverse effects as compared to the modern medicines. However, many herbal drugs and herbal extracts despite of their impressive in-vitro findings demonstrates less or negligible in-vivo activity due to their poor lipid solubility or ...
Kritika, Kesarwani, Rajiv, Gupta, Alok, Mukerjee   +2 more
openaire   +2 more sources

Unlocking the opportunities and challenges of green strategies for bioavailability enhancement of polyphenols

Frontiers in Food Science and Technology
Polyphenols are among the most versatile secondary metabolites of plants, with significant therapeutic potential, including anti-inflammatory, cardioprotective, and antioxidant properties.
Arya Ojha, Sweta Acharya, Adarsh Sharma, Vivek S. S. Chougule, Nishi Mody, Ankit Jain   +5 more
doaj   +1 more source

Bioavailability enhancement of curcumin via esterification processes: A review

European Journal of Medicinal Chemistry Reports, 2022
Turmeric (Curcuma longa) has been used in the form of kitchen spices since ancient times. It is a traditional medicine of Ayurveda and Chinese medicine in which curcuminoids are present as a major constituent.
Nidhi Agrawal, Meenakshi Jaiswal
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source