Results 11 to 20 of about 991,955 (291)

Bioavailability enhancement [PDF]

World Journal of Advanced Research and Reviews, 2023
The rate and extent (amount) of unmodified medication absorption from its dose form is referred to as bioavailability. It is one of the critical criteria for achieving optimal medication concentration in the systemic circulation. Bioavailability is a significant factor of a drug's therapeutic efficacy, which is determined by the drug's solubility in ...
Vaishnavi Tejram Gabhane, Akanksha Ravindra Ashtankar, Swati Vinayak Dongre, Vaibhav P. Uplanchiwar, Vinod M. Thakare, Abhishek Mohan Pimpale   +5 more
openaire   +2 more sources

Bioavailability enhancement of petroleum-contaminated soil by electrokinetic remediation [PDF]

E3S Web of Conferences
The Electro kinetic Remediation Technology (EKR) is recognized as the most potential remediation technology for soils with low permeability, like clay soil characteristics.
Madonna Sandra, Effendi Agus Jatnika, Kardena Edwan, Hidayat Syarif   +3 more
doaj   +2 more sources

Atorvastatin solid dispersion for bioavailability enhancement

Journal of Advanced Pharmaceutical Technology & Research, 2016
Atorvastatin calcium is a lipid-lowering agent. It has approximately 15% of bioavailability, remaining amount of drug showed adverse effect which is undesirable for patients.
Shamsuddin, Mohammad Fazil, Shahid H Ansari, Javed Ali   +3 more
doaj   +3 more sources

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Pharmaceuticals, 2021
One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor ...
Bharti Gupta, Varsha Mishra, Sankalp Gharat, Munira Momin, Abdelwahab Omri   +4 more
doaj   +2 more sources

Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. [PDF]

Biomedicines, 2022
The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with
Bhalani DV, Nutan B, Kumar A, Singh Chandel AK.   +3 more
europepmc   +2 more sources

Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

International Journal of Nanomedicine, 2012
Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic ...
Cha KH, Cho KJ, Kim MS, Kim JS, Park HJ, Park J, Cho W, Park JS, Hwang SJ   +8 more
doaj   +1 more source

Quality and In Vivo Assessment of a Fulvic Acid Complex: A Validation Study

Scientia Pharmaceutica, 2022
The present work aimed to re-assess the bioavailability enhancement potential of fulvic acid (FA). Carbamazepine (CBZ) and peat were used as a model drug and FA source, respectively.
Rahmuddin Khan, Pooja Jain, Foziyah Zakir, Mohd Aqil, Sameer Alshehri, Mohd Aamir Mirza, Zeenat Iqbal   +6 more
doaj   +1 more source

Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability

Pharmaceutics, 2023
(1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)—a new anticoagulation drug—has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10−6 cm/s across
Juseung Lee, Jong-Ju Lee, Seungyeol Lee, Linh Dinh, Hangyu Oh, Sharif Md Abuzar, Jun-Hyun Ahn, Sung-Joo Hwang   +7 more
doaj   +1 more source

Polymers Enhancing Bioavailability in Drug Delivery

Pharmaceutics, 2022
A drug’s bioavailability, i.e., the extent to and rate at which it enters the systemic circulation, thus accessing the site of action, is largely determined by the properties of the drug [...]
Ana I. Fernandes, Angela F. Jozala
openaire   +5 more sources

In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets

Pharmaceutics, 2021
Amorphous solid dispersion (ASD) dosage forms can improve the oral bioavailability of poorly water-soluble drugs, enabling the commercialization of new chemical entities and improving the efficacy and patient compliance of existing drugs.
Deanna M. Mudie, Aaron M. Stewart, Jesus A. Rosales, Molly S. Adam, Michael M. Morgen, David T. Vodak   +5 more
doaj   +1 more source