Atorvastatin solid dispersion for bioavailability enhancement
Journal of Advanced Pharmaceutical Technology & Research, 2016 Atorvastatin calcium is a lipid-lowering agent. It has approximately 15% of bioavailability, remaining amount of drug showed adverse effect which is undesirable for patients. The objective of the study was to enhance the solubility and a dissolution profile of the atorvastatin (AT) calcium.
Shamsuddin +3 more
openaire +4 more sources
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. [PDF]
Biomedicines, 2022 The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with
Bhalani DV +3 more
europepmc +2 more sources
Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides. [PDF]
Molecules, 2021 Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects.
Shao H +6 more
europepmc +2 more sources
Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability enhancement; in vitro and in vivo assessment. [PDF]
Saudi Pharm J, 2023 Itraconazole (ITZ) is a renowned antifungal medication, however its therapeutic efficacy is limited by low solubility and oral bioavailability. The current research work attempted to augment the oral bioavailability of ITZ by incorporating into self ...
Islam N +8 more
europepmc +2 more sources
Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review. [PDF]
PharmaceuticsThe oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the oral cavity, offering an alternative to enteral administration by bypassing the harsh ...
Bácskay I +10 more
europepmc +2 more sources
Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement. [PDF]
Bioengineering (Basel), 2018 The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs).
Kevadiya BD +6 more
europepmc +2 more sources
In-Vitro and In-Vivo Evaluation of Velpatasvir- Loaded Mesoporous Silica Scaffolds. A Prospective Carrier for Drug Bioavailability Enhancement. [PDF]
Pharmaceutics, 2020 The limited aqueous solubility of many active pharmaceutical ingredients (APIs) is responsible for their poor performance and low drug levels in blood and at target sites. Various approaches have been adopted to tackle this issue.
Mehmood Y +12 more
europepmc +2 more sources
LIQUISOLID TECHNIQUE FOR DISSOLUTION AND BIOAVAILABILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS [PDF]
, 2017 Liquisolid formulations have attracted substantial interest as an efficient means of improving the dissolution and ultimately bioavailability. The technique is based upon the admixture of drug loaded solutions with appropriate carrier, coating materials ...
null null +2 more
core +1 more source
, 2021 The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Artemisinin (ART) is a most promising antimalarial agent, which is both effective and well-tolerated in ...
Masania, Jinit +8 more
core +3 more sources
Nanocarriers for oral bioavailability enhancement
, 2009 Le but général de ce travail correspond à l'amélioration de la biodisponibilité de principes actifs connus pour leur faible biodisponibilité (testostérone) ou pour leur caractère lipidique (acides gras oméga 3). Des systèmes nanoparticulaires à base de lipides et des systèmes nanocristaux ont été développés notamment dans le cas de la testostérone ...
MUCHOW, Marc +2 more
openaire +2 more sources